Eogt protein (fruit fly) - STRING interaction network
"Eogt" - EGF domain-specific O-linked N-acetylglucosamine transferase in Drosophila melanogaster
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
protein homology
Your Input:
Gene Fusion
EogtEGF domain-specific O-linked N-acetylglucosamine transferase; Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in extracellular proteins resulting in their modification with a beta-linked N- acetylglucosamine (O-GlcNAc). Specifically glycosylates the Thr residue located between the fifth and sixth conserved cysteines of folded EGF-like domains. Involved in epithelial cell adhesion/interaction with the extracellular matrix by mediating glycosylation of proteins in the secretory pathway, such as Dumpy (Dp) (520 aa)    
Predicted Functional Partners:
Dystroglycan, isoform D; Dystroglycan is a major non-integrin ECM receptor that connects the extracellular matrix to the actin cytoskeleton. It regulates animal survival and temperature preference, muscle integrity, myotendinous and neuromuscular junction formation and function, nervous system development, axon pathfinding, rhabdomere differentiation, neuronal stem cell division and epithelial polarity (1262 aa)
Super sex combs, isoform A; Transferase activity, transferring glycosyl groups; acetylglucosaminyltransferase activity. It is involved in the biological process described with- wing disc development; protein glycosylation; locomotor rhythm (1059 aa)
Dumpy, isoform Q; Extracellular matrix structural constituent; 4 iron, 4 sulfur cluster binding; calcium ion binding. It is involved in the biological process described with- lateral inhibition; chitin-based cuticle attachment to epithelium; chitin-based embryonic cuticle biosynthetic process; apposition of dorsal and ventral imaginal disc-derived wing surfaces; open tracheal system development (22949 aa)
Mitf, isoform C; Protein dimerization activity. It is involved in the biological process described with- compound eye morphogenesis; regulation of transcription, DNA-templated (837 aa)
Neurogenic locus Notch protein; Signaling protein, which regulates, with both positive and negative signals, the differentiation of at least central and peripheral nervous system and eye, wing disk, oogenesis, segmental appendages such as antennae and legs, and muscles, through lateral inhibition or induction. Functions as a receptor for membrane- bound ligands Delta and Serrate to regulate cell-fate determination. Upon ligand activation, and releasing from the cell membrane, the Notch intracellular domain (NICD) forms a transcriptional activator complex with Su(H) (Suppressor of hairl [...] (2703 aa)
COP9 signalosome complex subunit 3; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in oogenesis and embryogenesis and is required for proper photoreceptor R cell differentiation and promote lamina glial cell migration or axon targeting. It also promotes [...] (445 aa)
Protein CLEC16A homolog; Required for mitophagy, autophagy and endosome maturation, possibly by acting in multiple membrane trafficking pathways. Required for endosome trafficking and maturation. Functions with the class C Vps-HOPS complex member Vps16a to promote endosomal maturation into degradative late endosomes and lysosomes. In response to starvation, functions at an early stage of autophagy to promote autophagosome growth and efficient autophagy. Essential for the recruitment of lva-positive Golgi elements to autophagosomes. Likely to function by promoting membrane traffic from [...] (1067 aa)
Cytosolic Fe-S cluster assembly factor NUBP1 homolog; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins (311 aa)
Uridine 5’-monophosphate synthase; Orotidine-5’-phosphate decarboxylase activity; orotate phosphoribosyltransferase activity. It is involved in the biological process described with- ’de novo’ pyrimidine nucleobase biosynthetic process; ’de novo’ UMP biosynthetic process; In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family (493 aa)
FI19713p1; Sequence-specific DNA binding transcription factor activity; Rab GTPase binding (933 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
Server load: low (12%) [HD]