Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of proteins in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Med | babo | FBpp0307959 | FBpp0087739 | Mothers against decapentaplegic homolog; Medea (Med) encodes a protein that belongs to the highly conserved Smad family. It can bind its siblings encoded by Mad or Smox to facilitate signal transduction for the product of dpp or Activin ligands in the TGF-beta family. Med-complexes function as transcriptional regulators. Many developmental roles include dorsal-ventral patterning, patterning and proliferation of the wing disc and gene expression in the mushroom body of the larval brain. | Receptor protein serine/threonine kinase; Baboon (babo) encodes the type I receptor for the activin-like ligands encoded by daw, Actbeta and myo. There are three isoforms of the product of babo that differ only in their extracellular domain likely resulting in different ligand binding specificity. It can form a complex with the type II receptors put or wit in the presence of an activin like ligand. This results in the transcriptional regulation of activin responsive genes; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | 0.819 |
| Med | dpp | FBpp0307959 | FBpp0077453 | Mothers against decapentaplegic homolog; Medea (Med) encodes a protein that belongs to the highly conserved Smad family. It can bind its siblings encoded by Mad or Smox to facilitate signal transduction for the product of dpp or Activin ligands in the TGF-beta family. Med-complexes function as transcriptional regulators. Many developmental roles include dorsal-ventral patterning, patterning and proliferation of the wing disc and gene expression in the mushroom body of the larval brain. | Protein decapentaplegic; Required during oogenesis for eggshell patterning and dorsal/ventral patterning of the embryo. Acts as a morphogen during embryogenesis to pattern the dorsal/ventral axis, specifying dorsal ectoderm and amnioserosa cell fate within the dorsal half of the embryo; this activity is antagonized by binding to sog and tsg. Induces the formation of visceral mesoderm and the heart in early embryos. Required later in embryogenesis for dorsal closure and patterning of the hindgut. Also functions postembryonically as a long-range morphogen during imaginal disk development [...] | 0.970 |
| Med | gbb | FBpp0307959 | FBpp0072036 | Mothers against decapentaplegic homolog; Medea (Med) encodes a protein that belongs to the highly conserved Smad family. It can bind its siblings encoded by Mad or Smox to facilitate signal transduction for the product of dpp or Activin ligands in the TGF-beta family. Med-complexes function as transcriptional regulators. Many developmental roles include dorsal-ventral patterning, patterning and proliferation of the wing disc and gene expression in the mushroom body of the larval brain. | Protein 60A; Glass bottom boat (gbb) encodes a BMP ligand in the TGF-beta/BMP family of dimeric signaling molecules. It binds to a receptor complex to transduce signal through phosphorylation of the product of Mad. It contributes to maintain stem cell populations, control cell fate specification, proliferation, synapse growth and neuropeptide release. | 0.836 |
| Med | hh | FBpp0307959 | FBpp0099945 | Mothers against decapentaplegic homolog; Medea (Med) encodes a protein that belongs to the highly conserved Smad family. It can bind its siblings encoded by Mad or Smox to facilitate signal transduction for the product of dpp or Activin ligands in the TGF-beta family. Med-complexes function as transcriptional regulators. Many developmental roles include dorsal-ventral patterning, patterning and proliferation of the wing disc and gene expression in the mushroom body of the larval brain. | Protein hedgehog C-product; Intercellular signal essential for a variety of patterning events during development. Establishes the anterior-posterior axis of the embryonic segments and patterns the larval imaginal disks. Binds to the patched (ptc) receptor, which functions in association with smoothened (smo), to activate the transcription of target genes wingless (wg), decapentaplegic (dpp) and ptc. In the absence of hh, ptc represses the constitutive signaling activity of smo through fused (fu). Essential component of a signaling pathway which regulates the Duox-dependent gut immune r [...] | 0.643 |
| Med | put | FBpp0307959 | FBpp0303260 | Mothers against decapentaplegic homolog; Medea (Med) encodes a protein that belongs to the highly conserved Smad family. It can bind its siblings encoded by Mad or Smox to facilitate signal transduction for the product of dpp or Activin ligands in the TGF-beta family. Med-complexes function as transcriptional regulators. Many developmental roles include dorsal-ventral patterning, patterning and proliferation of the wing disc and gene expression in the mushroom body of the larval brain. | Serine/threonine-protein kinase receptor; Punt (put) encodes a transforming growth factor beta type II receptor that functions in both Dpp/BMP and Activin signaling. Pathway specificity in signaling output is determined by which type I receptor (Dpp/BMP or Activin one) is engaged in the complex with the product of put; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | 0.891 |
| Med | sax | FBpp0307959 | FBpp0300982 | Mothers against decapentaplegic homolog; Medea (Med) encodes a protein that belongs to the highly conserved Smad family. It can bind its siblings encoded by Mad or Smox to facilitate signal transduction for the product of dpp or Activin ligands in the TGF-beta family. Med-complexes function as transcriptional regulators. Many developmental roles include dorsal-ventral patterning, patterning and proliferation of the wing disc and gene expression in the mushroom body of the larval brain. | Receptor protein serine/threonine kinase; Saxophone (sax) encodes a type I BMP receptor. Together with the BMP receptors encoded by tkv and put, it transduces signaling of the BMP ligands encoded by dpp, gbb and scw, in a wide variety of developmental processes including embryonic and imaginal disc patterning; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | 0.696 |
| Med | sog | FBpp0307959 | FBpp0309304 | Mothers against decapentaplegic homolog; Medea (Med) encodes a protein that belongs to the highly conserved Smad family. It can bind its siblings encoded by Mad or Smox to facilitate signal transduction for the product of dpp or Activin ligands in the TGF-beta family. Med-complexes function as transcriptional regulators. Many developmental roles include dorsal-ventral patterning, patterning and proliferation of the wing disc and gene expression in the mushroom body of the larval brain. | Dorsal-ventral patterning protein Sog; Short gastrulation (sog) encodes a secreted BMP antagonist that is expressed in the embryonic ventral neuroectoderm. sog product promotes neural development by preventing dorsally produced dpp from diffusing into the neuroectoderm and suppressing expression of neural genes. sog protein also diffuses dorsally where it helps establish a BMP activity gradient essential for partitioning that domain into cells giving rise to the dorsal epidermis versus amnioserosa. | 0.845 |
| Med | tkv | FBpp0307959 | FBpp0078721 | Mothers against decapentaplegic homolog; Medea (Med) encodes a protein that belongs to the highly conserved Smad family. It can bind its siblings encoded by Mad or Smox to facilitate signal transduction for the product of dpp or Activin ligands in the TGF-beta family. Med-complexes function as transcriptional regulators. Many developmental roles include dorsal-ventral patterning, patterning and proliferation of the wing disc and gene expression in the mushroom body of the larval brain. | Receptor protein serine/threonine kinase; Thickveins (tkv) encodes a transforming growth factor beta type I receptor. Together with the product of put, it functions as a receptor of the product of dpp and therefore contributes to the BMP signaling pathway; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | 0.904 |
| Med | wg | FBpp0307959 | FBpp0079060 | Mothers against decapentaplegic homolog; Medea (Med) encodes a protein that belongs to the highly conserved Smad family. It can bind its siblings encoded by Mad or Smox to facilitate signal transduction for the product of dpp or Activin ligands in the TGF-beta family. Med-complexes function as transcriptional regulators. Many developmental roles include dorsal-ventral patterning, patterning and proliferation of the wing disc and gene expression in the mushroom body of the larval brain. | Protein wingless; Binds as a ligand to a family of frizzled seven-transmembrane receptors and acts through a cascade of genes on the nucleus. Segment polarity protein. May be a growth factor. Acts on neighboring cells to regulate at least one gene, the homeobox segmentation gene engrailed. Wg signal represses arm phosphorylation. Wg signaling operates by inactivating the sgg repression of engrailed autoactivation. Wg and Wnt2 have a role in the developing trachea and together are responsible for all dorsal trunk formation. Wg also acts in the developing epidermis. Acts as a morphogen, [...] | 0.514 |
| Med | wit | FBpp0307959 | FBpp0303105 | Mothers against decapentaplegic homolog; Medea (Med) encodes a protein that belongs to the highly conserved Smad family. It can bind its siblings encoded by Mad or Smox to facilitate signal transduction for the product of dpp or Activin ligands in the TGF-beta family. Med-complexes function as transcriptional regulators. Many developmental roles include dorsal-ventral patterning, patterning and proliferation of the wing disc and gene expression in the mushroom body of the larval brain. | Receptor protein serine/threonine kinase; Wishful thinking (wit) encodes a BMP Type II Receptor that, upon binding of the ligand encoded by gbb, makes a complex with either tkv or sax encoding BMP type I receptors. This complex initiates phosphorylation and nuclear translocation of the transcription factor encoded by Mad. wit product controls synaptic homeostasis and neurotransmission at the neuromusclular junction during larval development. It also regulates the peptidergic phenotype of several neurosecretory cells; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase [...] | 0.960 |
| babo | Med | FBpp0087739 | FBpp0307959 | Receptor protein serine/threonine kinase; Baboon (babo) encodes the type I receptor for the activin-like ligands encoded by daw, Actbeta and myo. There are three isoforms of the product of babo that differ only in their extracellular domain likely resulting in different ligand binding specificity. It can form a complex with the type II receptors put or wit in the presence of an activin like ligand. This results in the transcriptional regulation of activin responsive genes; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | Mothers against decapentaplegic homolog; Medea (Med) encodes a protein that belongs to the highly conserved Smad family. It can bind its siblings encoded by Mad or Smox to facilitate signal transduction for the product of dpp or Activin ligands in the TGF-beta family. Med-complexes function as transcriptional regulators. Many developmental roles include dorsal-ventral patterning, patterning and proliferation of the wing disc and gene expression in the mushroom body of the larval brain. | 0.819 |
| babo | dpp | FBpp0087739 | FBpp0077453 | Receptor protein serine/threonine kinase; Baboon (babo) encodes the type I receptor for the activin-like ligands encoded by daw, Actbeta and myo. There are three isoforms of the product of babo that differ only in their extracellular domain likely resulting in different ligand binding specificity. It can form a complex with the type II receptors put or wit in the presence of an activin like ligand. This results in the transcriptional regulation of activin responsive genes; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | Protein decapentaplegic; Required during oogenesis for eggshell patterning and dorsal/ventral patterning of the embryo. Acts as a morphogen during embryogenesis to pattern the dorsal/ventral axis, specifying dorsal ectoderm and amnioserosa cell fate within the dorsal half of the embryo; this activity is antagonized by binding to sog and tsg. Induces the formation of visceral mesoderm and the heart in early embryos. Required later in embryogenesis for dorsal closure and patterning of the hindgut. Also functions postembryonically as a long-range morphogen during imaginal disk development [...] | 0.956 |
| babo | gbb | FBpp0087739 | FBpp0072036 | Receptor protein serine/threonine kinase; Baboon (babo) encodes the type I receptor for the activin-like ligands encoded by daw, Actbeta and myo. There are three isoforms of the product of babo that differ only in their extracellular domain likely resulting in different ligand binding specificity. It can form a complex with the type II receptors put or wit in the presence of an activin like ligand. This results in the transcriptional regulation of activin responsive genes; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | Protein 60A; Glass bottom boat (gbb) encodes a BMP ligand in the TGF-beta/BMP family of dimeric signaling molecules. It binds to a receptor complex to transduce signal through phosphorylation of the product of Mad. It contributes to maintain stem cell populations, control cell fate specification, proliferation, synapse growth and neuropeptide release. | 0.846 |
| babo | hh | FBpp0087739 | FBpp0099945 | Receptor protein serine/threonine kinase; Baboon (babo) encodes the type I receptor for the activin-like ligands encoded by daw, Actbeta and myo. There are three isoforms of the product of babo that differ only in their extracellular domain likely resulting in different ligand binding specificity. It can form a complex with the type II receptors put or wit in the presence of an activin like ligand. This results in the transcriptional regulation of activin responsive genes; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | Protein hedgehog C-product; Intercellular signal essential for a variety of patterning events during development. Establishes the anterior-posterior axis of the embryonic segments and patterns the larval imaginal disks. Binds to the patched (ptc) receptor, which functions in association with smoothened (smo), to activate the transcription of target genes wingless (wg), decapentaplegic (dpp) and ptc. In the absence of hh, ptc represses the constitutive signaling activity of smo through fused (fu). Essential component of a signaling pathway which regulates the Duox-dependent gut immune r [...] | 0.411 |
| babo | put | FBpp0087739 | FBpp0303260 | Receptor protein serine/threonine kinase; Baboon (babo) encodes the type I receptor for the activin-like ligands encoded by daw, Actbeta and myo. There are three isoforms of the product of babo that differ only in their extracellular domain likely resulting in different ligand binding specificity. It can form a complex with the type II receptors put or wit in the presence of an activin like ligand. This results in the transcriptional regulation of activin responsive genes; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | Serine/threonine-protein kinase receptor; Punt (put) encodes a transforming growth factor beta type II receptor that functions in both Dpp/BMP and Activin signaling. Pathway specificity in signaling output is determined by which type I receptor (Dpp/BMP or Activin one) is engaged in the complex with the product of put; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | 0.949 |
| babo | tkv | FBpp0087739 | FBpp0078721 | Receptor protein serine/threonine kinase; Baboon (babo) encodes the type I receptor for the activin-like ligands encoded by daw, Actbeta and myo. There are three isoforms of the product of babo that differ only in their extracellular domain likely resulting in different ligand binding specificity. It can form a complex with the type II receptors put or wit in the presence of an activin like ligand. This results in the transcriptional regulation of activin responsive genes; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | Receptor protein serine/threonine kinase; Thickveins (tkv) encodes a transforming growth factor beta type I receptor. Together with the product of put, it functions as a receptor of the product of dpp and therefore contributes to the BMP signaling pathway; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | 0.605 |
| babo | wit | FBpp0087739 | FBpp0303105 | Receptor protein serine/threonine kinase; Baboon (babo) encodes the type I receptor for the activin-like ligands encoded by daw, Actbeta and myo. There are three isoforms of the product of babo that differ only in their extracellular domain likely resulting in different ligand binding specificity. It can form a complex with the type II receptors put or wit in the presence of an activin like ligand. This results in the transcriptional regulation of activin responsive genes; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | Receptor protein serine/threonine kinase; Wishful thinking (wit) encodes a BMP Type II Receptor that, upon binding of the ligand encoded by gbb, makes a complex with either tkv or sax encoding BMP type I receptors. This complex initiates phosphorylation and nuclear translocation of the transcription factor encoded by Mad. wit product controls synaptic homeostasis and neurotransmission at the neuromusclular junction during larval development. It also regulates the peptidergic phenotype of several neurosecretory cells; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase [...] | 0.834 |
| dpp | Med | FBpp0077453 | FBpp0307959 | Protein decapentaplegic; Required during oogenesis for eggshell patterning and dorsal/ventral patterning of the embryo. Acts as a morphogen during embryogenesis to pattern the dorsal/ventral axis, specifying dorsal ectoderm and amnioserosa cell fate within the dorsal half of the embryo; this activity is antagonized by binding to sog and tsg. Induces the formation of visceral mesoderm and the heart in early embryos. Required later in embryogenesis for dorsal closure and patterning of the hindgut. Also functions postembryonically as a long-range morphogen during imaginal disk development [...] | Mothers against decapentaplegic homolog; Medea (Med) encodes a protein that belongs to the highly conserved Smad family. It can bind its siblings encoded by Mad or Smox to facilitate signal transduction for the product of dpp or Activin ligands in the TGF-beta family. Med-complexes function as transcriptional regulators. Many developmental roles include dorsal-ventral patterning, patterning and proliferation of the wing disc and gene expression in the mushroom body of the larval brain. | 0.970 |
| dpp | babo | FBpp0077453 | FBpp0087739 | Protein decapentaplegic; Required during oogenesis for eggshell patterning and dorsal/ventral patterning of the embryo. Acts as a morphogen during embryogenesis to pattern the dorsal/ventral axis, specifying dorsal ectoderm and amnioserosa cell fate within the dorsal half of the embryo; this activity is antagonized by binding to sog and tsg. Induces the formation of visceral mesoderm and the heart in early embryos. Required later in embryogenesis for dorsal closure and patterning of the hindgut. Also functions postembryonically as a long-range morphogen during imaginal disk development [...] | Receptor protein serine/threonine kinase; Baboon (babo) encodes the type I receptor for the activin-like ligands encoded by daw, Actbeta and myo. There are three isoforms of the product of babo that differ only in their extracellular domain likely resulting in different ligand binding specificity. It can form a complex with the type II receptors put or wit in the presence of an activin like ligand. This results in the transcriptional regulation of activin responsive genes; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | 0.956 |
| dpp | gbb | FBpp0077453 | FBpp0072036 | Protein decapentaplegic; Required during oogenesis for eggshell patterning and dorsal/ventral patterning of the embryo. Acts as a morphogen during embryogenesis to pattern the dorsal/ventral axis, specifying dorsal ectoderm and amnioserosa cell fate within the dorsal half of the embryo; this activity is antagonized by binding to sog and tsg. Induces the formation of visceral mesoderm and the heart in early embryos. Required later in embryogenesis for dorsal closure and patterning of the hindgut. Also functions postembryonically as a long-range morphogen during imaginal disk development [...] | Protein 60A; Glass bottom boat (gbb) encodes a BMP ligand in the TGF-beta/BMP family of dimeric signaling molecules. It binds to a receptor complex to transduce signal through phosphorylation of the product of Mad. It contributes to maintain stem cell populations, control cell fate specification, proliferation, synapse growth and neuropeptide release. | 0.986 |
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