node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CG16791 | CG6766 | FBpp0083494 | FBpp0079892 | LP06548p. | FI04402p; It is involved in the biological process described with: retrograde protein transport, ER to cytosol; ubiquitin-dependent ERAD pathway. | 0.933 |
CG16791 | Der-1 | FBpp0083494 | FBpp0306799 | LP06548p. | Derlin-1; May be involved in the degradation process of specific misfolded endoplasmic reticulum (ER) luminal proteins. May also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. | 0.935 |
CG16791 | Der-2 | FBpp0083494 | FBpp0082758 | LP06548p. | Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family. | 0.933 |
CG16791 | Hsc70-3 | FBpp0083494 | FBpp0073447 | LP06548p. | Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen. Involved in the correct folding of proteins and degradation of misfolded proteins (By similarity). Acts as a key repressor of the unfolded protein response (UPR) (By similarity). | 0.663 |
CG16791 | Npl4 | FBpp0083494 | FBpp0084267 | LP06548p. | Nuclear protein localization protein 4 homolog; May be part of a complex that binds ubiquitinated proteins and that is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. Belongs to the NPL4 family. | 0.487 |
CG16791 | TER94 | FBpp0083494 | FBpp0111818 | LP06548p. | Transitional endoplasmic reticulum ATPase TER94; Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. Involved in the ubiquitin-proteasome system. Important for oskar mRNA localization and/ [...] | 0.646 |
CG16791 | Ufd1-like | FBpp0083494 | FBpp0075952 | LP06548p. | Ubiquitin fusion degradation protein 1 homolog; Functions at a post-ubiquitation step in the ubiquitin fusion degradation (UFD) pathway; Belongs to the UFD1 family. | 0.420 |
CG16791 | sip3 | FBpp0083494 | FBpp0303146 | LP06548p. | E3 ubiquitin-protein ligase HRD1; Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin- dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins. Protects cells from ER stress-induced apoptosis. Sequesters p53 in the cytoplasm and pro [...] | 0.933 |
CG6766 | CG16791 | FBpp0079892 | FBpp0083494 | FI04402p; It is involved in the biological process described with: retrograde protein transport, ER to cytosol; ubiquitin-dependent ERAD pathway. | LP06548p. | 0.933 |
CG6766 | Der-1 | FBpp0079892 | FBpp0306799 | FI04402p; It is involved in the biological process described with: retrograde protein transport, ER to cytosol; ubiquitin-dependent ERAD pathway. | Derlin-1; May be involved in the degradation process of specific misfolded endoplasmic reticulum (ER) luminal proteins. May also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. | 0.993 |
CG6766 | Der-2 | FBpp0079892 | FBpp0082758 | FI04402p; It is involved in the biological process described with: retrograde protein transport, ER to cytosol; ubiquitin-dependent ERAD pathway. | Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family. | 0.996 |
CG6766 | Hrd3 | FBpp0079892 | FBpp0302807 | FI04402p; It is involved in the biological process described with: retrograde protein transport, ER to cytosol; ubiquitin-dependent ERAD pathway. | HMG-coA reductase degradation 3, isoform A; It is involved in the biological process described with: ubiquitin-dependent ERAD pathway. | 0.997 |
CG6766 | Hsc70-3 | FBpp0079892 | FBpp0073447 | FI04402p; It is involved in the biological process described with: retrograde protein transport, ER to cytosol; ubiquitin-dependent ERAD pathway. | Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen. Involved in the correct folding of proteins and degradation of misfolded proteins (By similarity). Acts as a key repressor of the unfolded protein response (UPR) (By similarity). | 0.873 |
CG6766 | Npl4 | FBpp0079892 | FBpp0084267 | FI04402p; It is involved in the biological process described with: retrograde protein transport, ER to cytosol; ubiquitin-dependent ERAD pathway. | Nuclear protein localization protein 4 homolog; May be part of a complex that binds ubiquitinated proteins and that is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. Belongs to the NPL4 family. | 0.650 |
CG6766 | TER94 | FBpp0079892 | FBpp0111818 | FI04402p; It is involved in the biological process described with: retrograde protein transport, ER to cytosol; ubiquitin-dependent ERAD pathway. | Transitional endoplasmic reticulum ATPase TER94; Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. Involved in the ubiquitin-proteasome system. Important for oskar mRNA localization and/ [...] | 0.925 |
CG6766 | Ufd1-like | FBpp0079892 | FBpp0075952 | FI04402p; It is involved in the biological process described with: retrograde protein transport, ER to cytosol; ubiquitin-dependent ERAD pathway. | Ubiquitin fusion degradation protein 1 homolog; Functions at a post-ubiquitation step in the ubiquitin fusion degradation (UFD) pathway; Belongs to the UFD1 family. | 0.775 |
CG6766 | sip3 | FBpp0079892 | FBpp0303146 | FI04402p; It is involved in the biological process described with: retrograde protein transport, ER to cytosol; ubiquitin-dependent ERAD pathway. | E3 ubiquitin-protein ligase HRD1; Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin- dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins. Protects cells from ER stress-induced apoptosis. Sequesters p53 in the cytoplasm and pro [...] | 0.995 |
CG8209 | Der-1 | FBpp0076470 | FBpp0306799 | GM09977p; Nucleic acid binding. | Derlin-1; May be involved in the degradation process of specific misfolded endoplasmic reticulum (ER) luminal proteins. May also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. | 0.939 |
CG8209 | Der-2 | FBpp0076470 | FBpp0082758 | GM09977p; Nucleic acid binding. | Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family. | 0.732 |
CG8209 | Npl4 | FBpp0076470 | FBpp0084267 | GM09977p; Nucleic acid binding. | Nuclear protein localization protein 4 homolog; May be part of a complex that binds ubiquitinated proteins and that is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. Belongs to the NPL4 family. | 0.481 |