STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Npc2aNPC intracellular cholesterol transporter 2 homolog a; Functions redundantly with Npc2b in regulating sterol homeostasis and ecdysteroid biosynthesis, probably by controlling the availability of sterol substrate. (148 aa)    
Predicted Functional Partners:
Npc1a
Niemann-Pick type C-1a (Npc1a) encodes a cholesterol trafficking protein that contributes to sterol and ecdysone metabolism. It is involved in sperm individualization.
    
 0.999
Npc2c
Niemann-Pick type C-2c; Sterol binding. It is involved in the biological process described with: sterol transport; intracellular cholesterol transport.
     
 0.966
Npc2h
Niemann-Pick type C-2h (Npc2h) encodes a protein involved in immune signaling via interaction with lipopolysaccharides, lipid A, peptidoglycan and lipoteichoic acid.
     
 0.966
Npc2e
Niemann-Pick type C-2e (Npc2e) encodes a protein involved in the immune signaling pathway via interaction with lipopolysaccharide, lipid A, peptidoglycan and lipoteichoic acid.
     
 0.966
Npc2g
Niemann-Pick type C-2g, isoform A; Sterol binding. It is involved in the biological process described with: intracellular cholesterol transport; sterol transport; mesoderm development.
     
 0.964
Npc1b
NPC intracellular cholesterol transporter 1 homolog 1b; Important for cholesterol absorption at the midgut epithelium. Acts only in the early steps of sterol absorption, prior to Npc1a-dependent intracellular sterol trafficking. Belongs to the patched family.
    
 0.942
Npc2b
Niemann-Pick type C-2b, isoform A; Sterol binding. It is involved in the biological process described with: multicellular organism reproduction; ecdysteroid biosynthetic process; intracellular cholesterol transport; sterol transport.
  
 
0.917
Npc2d
Niemann-Pick type C-2d; Sterol binding. It is involved in the biological process described with: sterol transport; intracellular cholesterol transport.
      
 0.664
Cln3
Battenin.
      
 0.626
pio
Piopio, isoform B; Piopio (pio) encodes a zona pellucida (ZP) domain protein that mediates the adhesion of the apical epithelial surface and the overlying apical extracellular matrix.
      
 0.523
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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