| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CG7744 | Rim2 | FBpp0085719 | FBpp0077576 | FI17509p1; Lamin binding; actin filament binding. It is involved in the biological process described with: nuclear migration along microtubule. | Mitochondrial carrier protein Rim2; Mitochondrial transporter that imports purine and pyrimidine nucleotides into the mitochondria. Essential for maintaining mitochondrial structure and function. Appears to be important for mitochondrial gene transcription and mitochondrial respiration. | 0.744 |
| CG7744 | gus | FBpp0085719 | FBpp0301582 | FI17509p1; Lamin binding; actin filament binding. It is involved in the biological process described with: nuclear migration along microtubule. | Gustavus (gus) encodes a cullin-RING ubiquitin E3 ligase specificity receptor. It interacts genetically and physically with the product of Cul5, and putatively regulates stability of target proteins including the one encoded by vas. It is involved in oogenesis and germ cell maintenance. | 0.746 |
| Cypl | Rim2 | FBpp0072463 | FBpp0077576 | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. | Mitochondrial carrier protein Rim2; Mitochondrial transporter that imports purine and pyrimidine nucleotides into the mitochondria. Essential for maintaining mitochondrial structure and function. Appears to be important for mitochondrial gene transcription and mitochondrial respiration. | 0.819 |
| Gs1 | Rim2 | FBpp0077774 | FBpp0077576 | Glutamine synthetase 1 (Gs1) encodes the mitochondrial enzyme that uses glutamate and ammonia as substrates to synthesize glutamine, which is a precursor of purine and pyrimidine synthesis. An adequate level of maternally supplied Gs1 product activity is necessary in the early embryonic development. High level of glutamine in mitochondria causes megamitochondrial formation in cells. | Mitochondrial carrier protein Rim2; Mitochondrial transporter that imports purine and pyrimidine nucleotides into the mitochondria. Essential for maintaining mitochondrial structure and function. Appears to be important for mitochondrial gene transcription and mitochondrial respiration. | 0.764 |
| Gs1 | Synd | FBpp0077774 | FBpp0306775 | Glutamine synthetase 1 (Gs1) encodes the mitochondrial enzyme that uses glutamate and ammonia as substrates to synthesize glutamine, which is a precursor of purine and pyrimidine synthesis. An adequate level of maternally supplied Gs1 product activity is necessary in the early embryonic development. High level of glutamine in mitochondria causes megamitochondrial formation in cells. | Syndapin, isoform C; Lipid binding; phospholipid binding; cytoskeletal protein binding; protein binding. | 0.751 |
| Nmnat | Rim2 | FBpp0084124 | FBpp0077576 | Nicotinamide mononucleotide adenylyltransferase (Nmnat) encodes an essential enzyme in the NAD salvage pathway, catalyzing the last step of NAD synthesis. It is also a neuronal maintenance factor that protects neurons from excitotoxicity, environmental stress and protein misfolding induced degeneration. | Mitochondrial carrier protein Rim2; Mitochondrial transporter that imports purine and pyrimidine nucleotides into the mitochondria. Essential for maintaining mitochondrial structure and function. Appears to be important for mitochondrial gene transcription and mitochondrial respiration. | 0.682 |
| Rim2 | CG7744 | FBpp0077576 | FBpp0085719 | Mitochondrial carrier protein Rim2; Mitochondrial transporter that imports purine and pyrimidine nucleotides into the mitochondria. Essential for maintaining mitochondrial structure and function. Appears to be important for mitochondrial gene transcription and mitochondrial respiration. | FI17509p1; Lamin binding; actin filament binding. It is involved in the biological process described with: nuclear migration along microtubule. | 0.744 |
| Rim2 | Cypl | FBpp0077576 | FBpp0072463 | Mitochondrial carrier protein Rim2; Mitochondrial transporter that imports purine and pyrimidine nucleotides into the mitochondria. Essential for maintaining mitochondrial structure and function. Appears to be important for mitochondrial gene transcription and mitochondrial respiration. | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. | 0.819 |
| Rim2 | Gs1 | FBpp0077576 | FBpp0077774 | Mitochondrial carrier protein Rim2; Mitochondrial transporter that imports purine and pyrimidine nucleotides into the mitochondria. Essential for maintaining mitochondrial structure and function. Appears to be important for mitochondrial gene transcription and mitochondrial respiration. | Glutamine synthetase 1 (Gs1) encodes the mitochondrial enzyme that uses glutamate and ammonia as substrates to synthesize glutamine, which is a precursor of purine and pyrimidine synthesis. An adequate level of maternally supplied Gs1 product activity is necessary in the early embryonic development. High level of glutamine in mitochondria causes megamitochondrial formation in cells. | 0.764 |
| Rim2 | Nmnat | FBpp0077576 | FBpp0084124 | Mitochondrial carrier protein Rim2; Mitochondrial transporter that imports purine and pyrimidine nucleotides into the mitochondria. Essential for maintaining mitochondrial structure and function. Appears to be important for mitochondrial gene transcription and mitochondrial respiration. | Nicotinamide mononucleotide adenylyltransferase (Nmnat) encodes an essential enzyme in the NAD salvage pathway, catalyzing the last step of NAD synthesis. It is also a neuronal maintenance factor that protects neurons from excitotoxicity, environmental stress and protein misfolding induced degeneration. | 0.682 |
| Rim2 | Synd | FBpp0077576 | FBpp0306775 | Mitochondrial carrier protein Rim2; Mitochondrial transporter that imports purine and pyrimidine nucleotides into the mitochondria. Essential for maintaining mitochondrial structure and function. Appears to be important for mitochondrial gene transcription and mitochondrial respiration. | Syndapin, isoform C; Lipid binding; phospholipid binding; cytoskeletal protein binding; protein binding. | 0.696 |
| Rim2 | YME1L | FBpp0077576 | FBpp0293463 | Mitochondrial carrier protein Rim2; Mitochondrial transporter that imports purine and pyrimidine nucleotides into the mitochondria. Essential for maintaining mitochondrial structure and function. Appears to be important for mitochondrial gene transcription and mitochondrial respiration. | ATP-dependent zinc metalloprotease YME1L; ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane region. Plays an important role in regulating mitochondrial morphology and function by cleaving Opa1, giving rise to a form of Opa1 that promotes maintenance of normal mitochondrial structure and mitochondrial protein metabolism. Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria fr [...] | 0.720 |
| Rim2 | gus | FBpp0077576 | FBpp0301582 | Mitochondrial carrier protein Rim2; Mitochondrial transporter that imports purine and pyrimidine nucleotides into the mitochondria. Essential for maintaining mitochondrial structure and function. Appears to be important for mitochondrial gene transcription and mitochondrial respiration. | Gustavus (gus) encodes a cullin-RING ubiquitin E3 ligase specificity receptor. It interacts genetically and physically with the product of Cul5, and putatively regulates stability of target proteins including the one encoded by vas. It is involved in oogenesis and germ cell maintenance. | 0.729 |
| Rim2 | mbf1 | FBpp0077576 | FBpp0303170 | Mitochondrial carrier protein Rim2; Mitochondrial transporter that imports purine and pyrimidine nucleotides into the mitochondria. Essential for maintaining mitochondrial structure and function. Appears to be important for mitochondrial gene transcription and mitochondrial respiration. | Multiprotein bridging factor 1 (mbf1) encodes a transcriptional co-activator that bridges between sequence-specific transcriptional regulators and the product of Tbp. Under stress, the product of mbf1 in the cytoplasm can translocate into the nucleus and serve as a co-activator to induce stress-reponse genes. | 0.770 |
| Rim2 | mfrn | FBpp0077576 | FBpp0084635 | Mitochondrial carrier protein Rim2; Mitochondrial transporter that imports purine and pyrimidine nucleotides into the mitochondria. Essential for maintaining mitochondrial structure and function. Appears to be important for mitochondrial gene transcription and mitochondrial respiration. | Mitoferrin; Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.763 |
| Rim2 | pum | FBpp0077576 | FBpp0305823 | Mitochondrial carrier protein Rim2; Mitochondrial transporter that imports purine and pyrimidine nucleotides into the mitochondria. Essential for maintaining mitochondrial structure and function. Appears to be important for mitochondrial gene transcription and mitochondrial respiration. | Maternal protein pumilio; Sequence-specific RNA-binding protein that acts as a post- transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'- UGUANAUA-3', that is related to the Nanos Response Element (NRE). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of deadenylase complexes leading to translational inhibition and mRNA degradation (By similarity). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs. Me [...] | 0.830 |
| Synd | Gs1 | FBpp0306775 | FBpp0077774 | Syndapin, isoform C; Lipid binding; phospholipid binding; cytoskeletal protein binding; protein binding. | Glutamine synthetase 1 (Gs1) encodes the mitochondrial enzyme that uses glutamate and ammonia as substrates to synthesize glutamine, which is a precursor of purine and pyrimidine synthesis. An adequate level of maternally supplied Gs1 product activity is necessary in the early embryonic development. High level of glutamine in mitochondria causes megamitochondrial formation in cells. | 0.751 |
| Synd | Rim2 | FBpp0306775 | FBpp0077576 | Syndapin, isoform C; Lipid binding; phospholipid binding; cytoskeletal protein binding; protein binding. | Mitochondrial carrier protein Rim2; Mitochondrial transporter that imports purine and pyrimidine nucleotides into the mitochondria. Essential for maintaining mitochondrial structure and function. Appears to be important for mitochondrial gene transcription and mitochondrial respiration. | 0.696 |
| YME1L | Rim2 | FBpp0293463 | FBpp0077576 | ATP-dependent zinc metalloprotease YME1L; ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane region. Plays an important role in regulating mitochondrial morphology and function by cleaving Opa1, giving rise to a form of Opa1 that promotes maintenance of normal mitochondrial structure and mitochondrial protein metabolism. Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria fr [...] | Mitochondrial carrier protein Rim2; Mitochondrial transporter that imports purine and pyrimidine nucleotides into the mitochondria. Essential for maintaining mitochondrial structure and function. Appears to be important for mitochondrial gene transcription and mitochondrial respiration. | 0.720 |
| YME1L | pum | FBpp0293463 | FBpp0305823 | ATP-dependent zinc metalloprotease YME1L; ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane region. Plays an important role in regulating mitochondrial morphology and function by cleaving Opa1, giving rise to a form of Opa1 that promotes maintenance of normal mitochondrial structure and mitochondrial protein metabolism. Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria fr [...] | Maternal protein pumilio; Sequence-specific RNA-binding protein that acts as a post- transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'- UGUANAUA-3', that is related to the Nanos Response Element (NRE). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of deadenylase complexes leading to translational inhibition and mRNA degradation (By similarity). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs. Me [...] | 0.767 |
