| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Fife | Rab3 | FBpp0305807 | FBpp0087352 | Fife, isoform D; Fife (Fife) encodes a synaptic scaffolding protein that promotes neurotransmitter release and normal motor behavior. | Ras-related protein Rab-3; Rab3 (Rab3) encodes a member of a large family of Ras-like small GTPases. Localized primarily at the synapse, Rab3 product is involved in mechanisms that control synaptic development and function, including the regulation of active zone protein composition at the neuromuscular junction. | 0.625 |
| Fife | Rim | FBpp0305807 | FBpp0293558 | Fife, isoform D; Fife (Fife) encodes a synaptic scaffolding protein that promotes neurotransmitter release and normal motor behavior. | Rab3 interacting molecule (Rim) encodes a scaffolding protein at the synaptic active zone, with important roles in promoting neurotransmitter release. | 0.544 |
| Fife | Rim2 | FBpp0305807 | FBpp0077576 | Fife, isoform D; Fife (Fife) encodes a synaptic scaffolding protein that promotes neurotransmitter release and normal motor behavior. | Mitochondrial carrier protein Rim2; Mitochondrial transporter that imports purine and pyrimidine nucleotides into the mitochondria. Essential for maintaining mitochondrial structure and function. Appears to be important for mitochondrial gene transcription and mitochondrial respiration. | 0.544 |
| Gart | Gs1 | FBpp0308722 | FBpp0077774 | Trifunctional purine biosynthetic protein adenosine-3; GART trifunctional enzyme (Gart) encodes a multifunctional enzyme that exhibits phosphoribosylamine-glycine ligase, phosphoribosylformylglycinamidine cyclo-ligase and phosphoribosylglycinamide formyltransferase activities; In the N-terminal section; belongs to the GARS family. In the C-terminal section; belongs to the GART family. | Glutamine synthetase 1 (Gs1) encodes the mitochondrial enzyme that uses glutamate and ammonia as substrates to synthesize glutamine, which is a precursor of purine and pyrimidine synthesis. An adequate level of maternally supplied Gs1 product activity is necessary in the early embryonic development. High level of glutamine in mitochondria causes megamitochondrial formation in cells. | 0.417 |
| Gart | Mdh1 | FBpp0308722 | FBpp0311560 | Trifunctional purine biosynthetic protein adenosine-3; GART trifunctional enzyme (Gart) encodes a multifunctional enzyme that exhibits phosphoribosylamine-glycine ligase, phosphoribosylformylglycinamidine cyclo-ligase and phosphoribosylglycinamide formyltransferase activities; In the N-terminal section; belongs to the GARS family. In the C-terminal section; belongs to the GART family. | Malate dehydrogenase 1 (Mdh1) encodes a L-malate dehydrogenase involved in the interconversion of malate and oxaloacetate. | 0.491 |
| Gart | Nmnat | FBpp0308722 | FBpp0084124 | Trifunctional purine biosynthetic protein adenosine-3; GART trifunctional enzyme (Gart) encodes a multifunctional enzyme that exhibits phosphoribosylamine-glycine ligase, phosphoribosylformylglycinamidine cyclo-ligase and phosphoribosylglycinamide formyltransferase activities; In the N-terminal section; belongs to the GARS family. In the C-terminal section; belongs to the GART family. | Nicotinamide mononucleotide adenylyltransferase (Nmnat) encodes an essential enzyme in the NAD salvage pathway, catalyzing the last step of NAD synthesis. It is also a neuronal maintenance factor that protects neurons from excitotoxicity, environmental stress and protein misfolding induced degeneration. | 0.852 |
| Gart | Rim2 | FBpp0308722 | FBpp0077576 | Trifunctional purine biosynthetic protein adenosine-3; GART trifunctional enzyme (Gart) encodes a multifunctional enzyme that exhibits phosphoribosylamine-glycine ligase, phosphoribosylformylglycinamidine cyclo-ligase and phosphoribosylglycinamide formyltransferase activities; In the N-terminal section; belongs to the GARS family. In the C-terminal section; belongs to the GART family. | Mitochondrial carrier protein Rim2; Mitochondrial transporter that imports purine and pyrimidine nucleotides into the mitochondria. Essential for maintaining mitochondrial structure and function. Appears to be important for mitochondrial gene transcription and mitochondrial respiration. | 0.499 |
| Gart | Uro | FBpp0308722 | FBpp0079109 | Trifunctional purine biosynthetic protein adenosine-3; GART trifunctional enzyme (Gart) encodes a multifunctional enzyme that exhibits phosphoribosylamine-glycine ligase, phosphoribosylformylglycinamidine cyclo-ligase and phosphoribosylglycinamide formyltransferase activities; In the N-terminal section; belongs to the GARS family. In the C-terminal section; belongs to the GART family. | Uricase; Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin. | 0.534 |
| Gs1 | Gart | FBpp0077774 | FBpp0308722 | Glutamine synthetase 1 (Gs1) encodes the mitochondrial enzyme that uses glutamate and ammonia as substrates to synthesize glutamine, which is a precursor of purine and pyrimidine synthesis. An adequate level of maternally supplied Gs1 product activity is necessary in the early embryonic development. High level of glutamine in mitochondria causes megamitochondrial formation in cells. | Trifunctional purine biosynthetic protein adenosine-3; GART trifunctional enzyme (Gart) encodes a multifunctional enzyme that exhibits phosphoribosylamine-glycine ligase, phosphoribosylformylglycinamidine cyclo-ligase and phosphoribosylglycinamide formyltransferase activities; In the N-terminal section; belongs to the GARS family. In the C-terminal section; belongs to the GART family. | 0.417 |
| Gs1 | Rim2 | FBpp0077774 | FBpp0077576 | Glutamine synthetase 1 (Gs1) encodes the mitochondrial enzyme that uses glutamate and ammonia as substrates to synthesize glutamine, which is a precursor of purine and pyrimidine synthesis. An adequate level of maternally supplied Gs1 product activity is necessary in the early embryonic development. High level of glutamine in mitochondria causes megamitochondrial formation in cells. | Mitochondrial carrier protein Rim2; Mitochondrial transporter that imports purine and pyrimidine nucleotides into the mitochondria. Essential for maintaining mitochondrial structure and function. Appears to be important for mitochondrial gene transcription and mitochondrial respiration. | 0.545 |
| Gs1 | Uro | FBpp0077774 | FBpp0079109 | Glutamine synthetase 1 (Gs1) encodes the mitochondrial enzyme that uses glutamate and ammonia as substrates to synthesize glutamine, which is a precursor of purine and pyrimidine synthesis. An adequate level of maternally supplied Gs1 product activity is necessary in the early embryonic development. High level of glutamine in mitochondria causes megamitochondrial formation in cells. | Uricase; Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin. | 0.491 |
| Mdh1 | Gart | FBpp0311560 | FBpp0308722 | Malate dehydrogenase 1 (Mdh1) encodes a L-malate dehydrogenase involved in the interconversion of malate and oxaloacetate. | Trifunctional purine biosynthetic protein adenosine-3; GART trifunctional enzyme (Gart) encodes a multifunctional enzyme that exhibits phosphoribosylamine-glycine ligase, phosphoribosylformylglycinamidine cyclo-ligase and phosphoribosylglycinamide formyltransferase activities; In the N-terminal section; belongs to the GARS family. In the C-terminal section; belongs to the GART family. | 0.491 |
| Mdh1 | Rim2 | FBpp0311560 | FBpp0077576 | Malate dehydrogenase 1 (Mdh1) encodes a L-malate dehydrogenase involved in the interconversion of malate and oxaloacetate. | Mitochondrial carrier protein Rim2; Mitochondrial transporter that imports purine and pyrimidine nucleotides into the mitochondria. Essential for maintaining mitochondrial structure and function. Appears to be important for mitochondrial gene transcription and mitochondrial respiration. | 0.533 |
| Mdh1 | YME1L | FBpp0311560 | FBpp0293463 | Malate dehydrogenase 1 (Mdh1) encodes a L-malate dehydrogenase involved in the interconversion of malate and oxaloacetate. | ATP-dependent zinc metalloprotease YME1L; ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane region. Plays an important role in regulating mitochondrial morphology and function by cleaving Opa1, giving rise to a form of Opa1 that promotes maintenance of normal mitochondrial structure and mitochondrial protein metabolism. Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria fr [...] | 0.454 |
| Nmnat | Gart | FBpp0084124 | FBpp0308722 | Nicotinamide mononucleotide adenylyltransferase (Nmnat) encodes an essential enzyme in the NAD salvage pathway, catalyzing the last step of NAD synthesis. It is also a neuronal maintenance factor that protects neurons from excitotoxicity, environmental stress and protein misfolding induced degeneration. | Trifunctional purine biosynthetic protein adenosine-3; GART trifunctional enzyme (Gart) encodes a multifunctional enzyme that exhibits phosphoribosylamine-glycine ligase, phosphoribosylformylglycinamidine cyclo-ligase and phosphoribosylglycinamide formyltransferase activities; In the N-terminal section; belongs to the GARS family. In the C-terminal section; belongs to the GART family. | 0.852 |
| Nmnat | Rim2 | FBpp0084124 | FBpp0077576 | Nicotinamide mononucleotide adenylyltransferase (Nmnat) encodes an essential enzyme in the NAD salvage pathway, catalyzing the last step of NAD synthesis. It is also a neuronal maintenance factor that protects neurons from excitotoxicity, environmental stress and protein misfolding induced degeneration. | Mitochondrial carrier protein Rim2; Mitochondrial transporter that imports purine and pyrimidine nucleotides into the mitochondria. Essential for maintaining mitochondrial structure and function. Appears to be important for mitochondrial gene transcription and mitochondrial respiration. | 0.600 |
| Rab3 | Fife | FBpp0087352 | FBpp0305807 | Ras-related protein Rab-3; Rab3 (Rab3) encodes a member of a large family of Ras-like small GTPases. Localized primarily at the synapse, Rab3 product is involved in mechanisms that control synaptic development and function, including the regulation of active zone protein composition at the neuromuscular junction. | Fife, isoform D; Fife (Fife) encodes a synaptic scaffolding protein that promotes neurotransmitter release and normal motor behavior. | 0.625 |
| Rab3 | Rim | FBpp0087352 | FBpp0293558 | Ras-related protein Rab-3; Rab3 (Rab3) encodes a member of a large family of Ras-like small GTPases. Localized primarily at the synapse, Rab3 product is involved in mechanisms that control synaptic development and function, including the regulation of active zone protein composition at the neuromuscular junction. | Rab3 interacting molecule (Rim) encodes a scaffolding protein at the synaptic active zone, with important roles in promoting neurotransmitter release. | 0.997 |
| Rab3 | Rim2 | FBpp0087352 | FBpp0077576 | Ras-related protein Rab-3; Rab3 (Rab3) encodes a member of a large family of Ras-like small GTPases. Localized primarily at the synapse, Rab3 product is involved in mechanisms that control synaptic development and function, including the regulation of active zone protein composition at the neuromuscular junction. | Mitochondrial carrier protein Rim2; Mitochondrial transporter that imports purine and pyrimidine nucleotides into the mitochondria. Essential for maintaining mitochondrial structure and function. Appears to be important for mitochondrial gene transcription and mitochondrial respiration. | 0.564 |
| Rim | Fife | FBpp0293558 | FBpp0305807 | Rab3 interacting molecule (Rim) encodes a scaffolding protein at the synaptic active zone, with important roles in promoting neurotransmitter release. | Fife, isoform D; Fife (Fife) encodes a synaptic scaffolding protein that promotes neurotransmitter release and normal motor behavior. | 0.544 |