Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Nnf1bRE44027p; Nnf1b (Nnf1b) encodes a component of the Mis12 complex, which is an essential constituent of the kinetochore. (204 aa)    
Predicted Functional Partners:
Mis12
RE19545p; Mis12 (Mis12) encodes a protein involved in chromosome movement and metaphase plate congression during mitosis.
   
 0.999
Spc25
Kinetochore protein Spc25; Acts as a component of the essential kinetochore-associated Ndc80 complex, which is required for chromosome segregation and spindle checkpoint activity during meiosis and mitosis. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. Participates in SAC signaling that responds specifically to disruptions in spindle microtubule dynamics. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing [...]
   
 0.996
Kmn1
Kinetochore Mis12-Ndc80 network component 1 (Kmn1) encodes a protein involved in the movement of chromosomes during mitosis.
   
 0.994
Spc105R
Spc105-related, isoform B; Spc105-related (Spc105R) encodes an essential component of the kinetochore, to which it is recruited by binding to the Mis12 kinetochore complex. The products of Spc105R and Mis12 recruit the Ndc80 complex, which provides the major microtubule binding activity of the kinetochore.
   
 0.988
Ndc80
LD33040p; Ndc80 (Ndc80) encodes a protein involved in mitotic metaphase plate congression.
   
 0.981
Nuf2
Nuf2 (Nuf2) encodes a protein involved in mitotic metaphase plate congression.
   
 0.981
Kmn2
Kinetochore Mis12-Ndc80 network component 2 (Kmn2) encodes a component of the Ndc80 complex, an essential kinetochore constituent.
     
 0.977
Nnf1a
RE42502p; Nnf1a (Nnf1a) encodes a component of the Mis12 complex, which is an essential constituent of the kinetochore.
   
0.949
Mps1
Monopolar spindle 1, isoform B; Monopolar spindle 1 (Mps1) encodes a conserved protein kinase that is associated with kinetochores and is required for the mitotic and meiotic spindle assembly checkpoints.
   
 
  0.906
lwr
Lesswright (lwr) encodes Ubc9, a SUMO conjugating enzyme that accepts SUMO from the SUMO activating enzyme and hands it off to the SUMO conjugation target. It has documented biological functions in innate immunity, meiosis, and anterior patterning of the embryo.
   
 
  0.904
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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