STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Nnf1bRE44027p; Nnf1b (Nnf1b) encodes a component of the Mis12 complex, which is an essential constituent of the kinetochore. (204 aa)    
Predicted Functional Partners:
Mis12
RE19545p; Mis12 (Mis12) encodes a protein involved in chromosome movement and metaphase plate congression during mitosis.
   
 0.995
Kmn1
Kinetochore Mis12-Ndc80 network component 1 (Kmn1) encodes a protein involved in the movement of chromosomes during mitosis.
   
 0.993
Spc25
Kinetochore protein Spc25; Acts as a component of the essential kinetochore-associated Ndc80 complex, which is required for chromosome segregation and spindle checkpoint activity during meiosis and mitosis. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. Participates in SAC signaling that responds specifically to disruptions in spindle microtubule dynamics. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing [...]
   
 0.992
Kmn2
Kinetochore Mis12-Ndc80 network component 2 (Kmn2) encodes a component of the Ndc80 complex, an essential kinetochore constituent.
     
 0.978
Nuf2
Nuf2 (Nuf2) encodes a protein involved in mitotic metaphase plate congression.
   
 0.976
Ndc80
LD33040p; Ndc80 (Ndc80) encodes a protein involved in mitotic metaphase plate congression.
   
 0.963
Nnf1a
RE42502p; Nnf1a (Nnf1a) encodes a component of the Mis12 complex, which is an essential constituent of the kinetochore.
   
0.958
Spc105R
Spc105-related, isoform B; Spc105-related (Spc105R) encodes an essential component of the kinetochore, to which it is recruited by binding to the Mis12 kinetochore complex. The products of Spc105R and Mis12 recruit the Ndc80 complex, which provides the major microtubule binding activity of the kinetochore.
   
 
 0.928
Cenp-C
Centromeric protein-C (Cenp-C) encodes an essential centromere protein. It binds to the product of cid and provides a binding site for the Mis12 kinetochore protein complex, which is recruited to the centromere at the start of mitotic and meiotic M phases. It also binds the product of cal1, which is crucial for propagation of the epigenetic mark that specifies centromere identity during progression through the cell division cycle.
   
 
 0.761
cid
Histone H3-like centromeric protein cid; Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division.
   
  
 0.645
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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