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ninaA protein (fruit fly) - STRING interaction network
"ninaA" - Peptidyl-prolyl cis-trans isomerase, rhodopsin-specific isozyme in Drosophila melanogaster
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second shell of interactors
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ninaAPeptidyl-prolyl cis-trans isomerase, rhodopsin-specific isozyme; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts on the folding of rhodopsin RH1 and RH2 (but not RH3) and is required for visual transduction; Belongs to the cyclophilin-type PPIase family (237 aa)    
Predicted Functional Partners:
rtp
MORN repeat-containing protein 4 homolog; Plays a role in promoting axonal degeneration following neuronal injury by toxic insult or trauma. Organizes rhabdomeric components to suppress random activation of the phototransduction cascade and thus increases the signaling fidelity of dark-adapted photoreceptors. The rtp/ninaC complex is required for stability of inad and inac and the normal termination of phototransduction in the retina (198 aa)
     
   
  0.793
FK506-bp2
12 kDa FK506-binding protein; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Binds to ligand-free TGF beta type I receptor, from which it is released upon a ligand-induced, type II receptor mediated phosphorylation of the type I receptor. Binding is inhibitory to the signaling pathways of the TGF beta family ligands (108 aa)
 
 
  0.766
ninaC
Neither inactivation nor afterpotential protein C; Required for photoreceptor cell function. The ninaC proteins combines putative serine/threonine-protein kinase and myosin activities. Essential for the expression and stability of the rtp protein in the photoreceptors. The rtp/ninaC complex is required for stability of inad and inac and the normal termination of phototransduction in the retina; In the C-terminal section; belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family (1501 aa)
     
 
  0.741
Cpn
Calphotin is a glutamic acid-rich protein with a strong negative charge and a highly hydrophobic amino acid composition. It functions as an immobile Ca[2+] buffer along the base of the photoreceptor’s microvilli. It protects the photoreceptor cells from Ca[2+] overload and light induced degeneration (864 aa)
     
   
  0.737
CG9150
CG9150; Oxidoreductase activity, acting on CH-OH group of donors. It is involved in the biological process described with- metabolic process; Belongs to the short-chain dehydrogenases/reductases (SDR) family (251 aa)
       
 
  0.701
Hsc70-3
Heat shock 70 kDa protein cognate 3; Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER (656 aa)
 
 
  0.689
stops
Slow termination of phototransduction, isoform A; It is involved in the biological process described with- intracellular signal transduction; sensory perception of sound; deactivation of rhodopsin mediated signaling (521 aa)
     
   
  0.674
Vps4
Vacuolar protein sorting 4, isoform A; ATP binding; ATPase activity. It is involved in the biological process described with- phagocytosis; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; negative regulation of growth of symbiont in host; negative regulation of Notch signaling pathway; establishment or maintenance of epithelial cell apical/basal polarity; actin cytoskeleton organization; autophagic vacuole fusion; intracellular protein transport (442 aa)
       
 
  0.673
FK506-bp1
39 kDa FK506-binding nuclear protein; PPIases accelerate the folding of proteins. May function in a signal transduction cascade during early development (357 aa)
   
 
  0.656
ptr
EG-BACH48C10.5 protein; Proximal to raf (1234 aa)
           
  0.644
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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