STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
shvDnaJ homolog shv; Maintains stem cell niche architecture in the testes. Activates an extracellular integrin beta-PS pathway which regulates DE- cadherin (shg) levels in somatic hub cells, and is essential for maintaining the number of germline stem cells and the structure and localization of hub cells. (354 aa)    
Predicted Functional Partners:
Gp93
Glycoprotein 93 (Gp93) encodes a heat shock protein Hsp90 family member that is involved in midgut development.
  
 
 0.977
P58IPK
LD25575p; Misfolded protein binding; chaperone binding. It is involved in the biological process described with: protein folding in endoplasmic reticulum.
   
0.976
Hsc70-3
Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen. Involved in the correct folding of proteins and degradation of misfolded proteins (By similarity). Acts as a key repressor of the unfolded protein response (UPR) (By similarity).
  
 
 0.973
CG7556
GH07340p; DNA binding.
   
0.919
CG32727
GEO10507p1; ATPase activator activity. It is involved in the biological process described with: protein import into mitochondrial matrix.
      
 0.914
Manf
Mesencephalic astrocyte-derived neurotrophic factor (Manf) encodes an evolutionarily conserved neurotrophic factor. It contributes to dopamine neuron survival, regulation of unfolded protein response and retinal repair.
   
  
 0.904
CaBP1
Protein disulfide-isomerase A6 homolog; Calcium-binding protein 1 (CaBP1) encodes a protein that resides in the lumen of the endoplasmic reticulum. It seems to be relocated outside cells during apoptosis and involved in the phagocytosis of apoptotic cells.
   
 
 0.901
CG11999
GH21273p; Dolichyl-phosphate-mannose-protein mannosyltransferase activity. It is involved in the biological process described with: ER-associated misfolded protein catabolic process; protein O-linked mannosylation.
   
 
 0.806
CG2918
EG:25E8.1 protein; It is involved in the biological process described with: multicellular organism reproduction; cellular response to hypoxia; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway.
  
 
 0.732
CG9911
LD41494p; Protein disulfide isomerase activity. It is involved in the biological process described with: cell redox homeostasis.
   
 
 0.723
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.