Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of proteins in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Kul | N | FBpp0308774 | FBpp0070483 | Kuzbanian-like, isoform A; Kuzbanian-like (Kul) encodes an ADAM metalloprotease involved in regulation of the Notch signaling pathway by cleaving the product of Dl. | Processed neurogenic locus Notch protein; Essential signaling protein which has a major role in many developmental processes. Functions as a receptor for membrane-bound ligands Delta and Serrate to regulate cell-fate determination. Upon ligand activation, and releasing from the cell membrane, the Notch intracellular domain (NICD) forms a transcriptional activator complex with Su(H) (Suppressor of hairless) and activates genes of the E(spl) complex. Regulates oogenesis, the differentiation of the ectoderm and the development of the central and peripheral nervous system, eye, wing disk, [...] | 0.685 |
| Kul | Nct | FBpp0308774 | FBpp0306637 | Kuzbanian-like, isoform A; Kuzbanian-like (Kul) encodes an ADAM metalloprotease involved in regulation of the Notch signaling pathway by cleaving the product of Dl. | Nicastrin; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch. It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex. | 0.893 |
| Kul | Psn | FBpp0308774 | FBpp0077850 | Kuzbanian-like, isoform A; Kuzbanian-like (Kul) encodes an ADAM metalloprotease involved in regulation of the Notch signaling pathway by cleaving the product of Dl. | Presenilin homolog; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptor. Required for S3 cleavage of Notch, which releases activated Notch protein from the cell membrane. Involved in the patterning of the optic lobes. Belongs to the peptidase A22A family. | 0.888 |
| Kul | pen-2 | FBpp0308774 | FBpp0309291 | Kuzbanian-like, isoform A; Kuzbanian-like (Kul) encodes an ADAM metalloprotease involved in regulation of the Notch signaling pathway by cleaving the product of Dl. | Gamma-secretase subunit pen-2; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch. It probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity. | 0.868 |
| Kul | tau | FBpp0308774 | FBpp0311078 | Kuzbanian-like, isoform A; Kuzbanian-like (Kul) encodes an ADAM metalloprotease involved in regulation of the Notch signaling pathway by cleaving the product of Dl. | Microtubule-associated protein; Microtubule binding. It is involved in the biological process described with: neuron projection development; rhabdomere morphogenesis; negative regulation of neuron death; microtubule cytoskeleton organization. | 0.465 |
| N | Kul | FBpp0070483 | FBpp0308774 | Processed neurogenic locus Notch protein; Essential signaling protein which has a major role in many developmental processes. Functions as a receptor for membrane-bound ligands Delta and Serrate to regulate cell-fate determination. Upon ligand activation, and releasing from the cell membrane, the Notch intracellular domain (NICD) forms a transcriptional activator complex with Su(H) (Suppressor of hairless) and activates genes of the E(spl) complex. Regulates oogenesis, the differentiation of the ectoderm and the development of the central and peripheral nervous system, eye, wing disk, [...] | Kuzbanian-like, isoform A; Kuzbanian-like (Kul) encodes an ADAM metalloprotease involved in regulation of the Notch signaling pathway by cleaving the product of Dl. | 0.685 |
| N | Nct | FBpp0070483 | FBpp0306637 | Processed neurogenic locus Notch protein; Essential signaling protein which has a major role in many developmental processes. Functions as a receptor for membrane-bound ligands Delta and Serrate to regulate cell-fate determination. Upon ligand activation, and releasing from the cell membrane, the Notch intracellular domain (NICD) forms a transcriptional activator complex with Su(H) (Suppressor of hairless) and activates genes of the E(spl) complex. Regulates oogenesis, the differentiation of the ectoderm and the development of the central and peripheral nervous system, eye, wing disk, [...] | Nicastrin; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch. It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex. | 0.985 |
| N | Psn | FBpp0070483 | FBpp0077850 | Processed neurogenic locus Notch protein; Essential signaling protein which has a major role in many developmental processes. Functions as a receptor for membrane-bound ligands Delta and Serrate to regulate cell-fate determination. Upon ligand activation, and releasing from the cell membrane, the Notch intracellular domain (NICD) forms a transcriptional activator complex with Su(H) (Suppressor of hairless) and activates genes of the E(spl) complex. Regulates oogenesis, the differentiation of the ectoderm and the development of the central and peripheral nervous system, eye, wing disk, [...] | Presenilin homolog; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptor. Required for S3 cleavage of Notch, which releases activated Notch protein from the cell membrane. Involved in the patterning of the optic lobes. Belongs to the peptidase A22A family. | 0.988 |
| N | aph-1 | FBpp0070483 | FBpp0307126 | Processed neurogenic locus Notch protein; Essential signaling protein which has a major role in many developmental processes. Functions as a receptor for membrane-bound ligands Delta and Serrate to regulate cell-fate determination. Upon ligand activation, and releasing from the cell membrane, the Notch intracellular domain (NICD) forms a transcriptional activator complex with Su(H) (Suppressor of hairless) and activates genes of the E(spl) complex. Regulates oogenesis, the differentiation of the ectoderm and the development of the central and peripheral nervous system, eye, wing disk, [...] | Gamma-secretase subunit Aph-1; Anterior pharynx defective 1 (aph-1) encodes a scaffolding subunit of the gamma-secretase complex together with the products of Psn, Nct and pen-2. It is involved in several Notch related processes such as differentiation, cellular organization and developmental patterning via gamma-secretase proteolitic function. | 0.921 |
| N | arm | FBpp0070483 | FBpp0089032 | Processed neurogenic locus Notch protein; Essential signaling protein which has a major role in many developmental processes. Functions as a receptor for membrane-bound ligands Delta and Serrate to regulate cell-fate determination. Upon ligand activation, and releasing from the cell membrane, the Notch intracellular domain (NICD) forms a transcriptional activator complex with Su(H) (Suppressor of hairless) and activates genes of the E(spl) complex. Regulates oogenesis, the differentiation of the ectoderm and the development of the central and peripheral nervous system, eye, wing disk, [...] | Armadillo segment polarity protein; Isoform neural may associate with CadN and participate in the transmission of developmental information. Can associate with alpha- catenin. Isoform cytoplasmic accumulates through wg signaling; arm function in wg signal transduction is required early in development for determination of neuroblast fate. Arm and Abl proteins function cooperatively at adherens junctions in both the CNS and epidermis. Belongs to the beta-catenin family. | 0.580 |
| N | kuz | FBpp0070483 | FBpp0080088 | Processed neurogenic locus Notch protein; Essential signaling protein which has a major role in many developmental processes. Functions as a receptor for membrane-bound ligands Delta and Serrate to regulate cell-fate determination. Upon ligand activation, and releasing from the cell membrane, the Notch intracellular domain (NICD) forms a transcriptional activator complex with Su(H) (Suppressor of hairless) and activates genes of the E(spl) complex. Regulates oogenesis, the differentiation of the ectoderm and the development of the central and peripheral nervous system, eye, wing disk, [...] | Kuzbanian, isoform A; Kuzbanian (kuz) encodes an ADAM metalloendopeptidase that regulates activation of the receptors encoded by N and robo1 by cleavage. | 0.904 |
| N | pen-2 | FBpp0070483 | FBpp0309291 | Processed neurogenic locus Notch protein; Essential signaling protein which has a major role in many developmental processes. Functions as a receptor for membrane-bound ligands Delta and Serrate to regulate cell-fate determination. Upon ligand activation, and releasing from the cell membrane, the Notch intracellular domain (NICD) forms a transcriptional activator complex with Su(H) (Suppressor of hairless) and activates genes of the E(spl) complex. Regulates oogenesis, the differentiation of the ectoderm and the development of the central and peripheral nervous system, eye, wing disk, [...] | Gamma-secretase subunit pen-2; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch. It probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity. | 0.940 |
| Nct | Kul | FBpp0306637 | FBpp0308774 | Nicastrin; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch. It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex. | Kuzbanian-like, isoform A; Kuzbanian-like (Kul) encodes an ADAM metalloprotease involved in regulation of the Notch signaling pathway by cleaving the product of Dl. | 0.893 |
| Nct | N | FBpp0306637 | FBpp0070483 | Nicastrin; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch. It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex. | Processed neurogenic locus Notch protein; Essential signaling protein which has a major role in many developmental processes. Functions as a receptor for membrane-bound ligands Delta and Serrate to regulate cell-fate determination. Upon ligand activation, and releasing from the cell membrane, the Notch intracellular domain (NICD) forms a transcriptional activator complex with Su(H) (Suppressor of hairless) and activates genes of the E(spl) complex. Regulates oogenesis, the differentiation of the ectoderm and the development of the central and peripheral nervous system, eye, wing disk, [...] | 0.985 |
| Nct | Psn | FBpp0306637 | FBpp0077850 | Nicastrin; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch. It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex. | Presenilin homolog; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptor. Required for S3 cleavage of Notch, which releases activated Notch protein from the cell membrane. Involved in the patterning of the optic lobes. Belongs to the peptidase A22A family. | 0.999 |
| Nct | aph-1 | FBpp0306637 | FBpp0307126 | Nicastrin; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch. It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex. | Gamma-secretase subunit Aph-1; Anterior pharynx defective 1 (aph-1) encodes a scaffolding subunit of the gamma-secretase complex together with the products of Psn, Nct and pen-2. It is involved in several Notch related processes such as differentiation, cellular organization and developmental patterning via gamma-secretase proteolitic function. | 0.999 |
| Nct | kuz | FBpp0306637 | FBpp0080088 | Nicastrin; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch. It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex. | Kuzbanian, isoform A; Kuzbanian (kuz) encodes an ADAM metalloendopeptidase that regulates activation of the receptors encoded by N and robo1 by cleavage. | 0.903 |
| Nct | pen-2 | FBpp0306637 | FBpp0309291 | Nicastrin; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch. It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex. | Gamma-secretase subunit pen-2; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch. It probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity. | 0.999 |
| Nct | tau | FBpp0306637 | FBpp0311078 | Nicastrin; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch. It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex. | Microtubule-associated protein; Microtubule binding. It is involved in the biological process described with: neuron projection development; rhabdomere morphogenesis; negative regulation of neuron death; microtubule cytoskeleton organization. | 0.542 |
| Pka-C1 | Pka-C2 | FBpp0089382 | FBpp0085089 | cAMP-dependent protein kinase catalytic subunit 1; Serine/threonine-protein kinase involved in memory formation. Promotes long-term memory by phosphorylating meng and by regulating CrebB protein stability and activity. As part of ethanol response in the glia, mediates ethanol-induced structural remodeling of actin cytoskeleton and perineurial membrane topology when anchored to the membrane. | ATP binding; protein serine/threonine kinase activity; cAMP-dependent protein kinase activity; protein kinase A regulatory subunit binding. It is involved in the biological process described with: protein kinase A signaling; peptidyl-serine phosphorylation. | 0.939 |
page 1 of 4