Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Hpd4-hydroxyphenylpyruvate dioxygenase activity. It is involved in the biological process described with: oxidation-reduction process; tyrosine catabolic process. (380 aa)    
Predicted Functional Partners:
hgo
Homogentisate 1,2-dioxygenase activity. It is involved in the biological process described with: L-phenylalanine catabolic process; oxidation-reduction process; cellular amino acid metabolic process; tyrosine metabolic process.
  
 0.999
CG1461
Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate.
   
 
 0.995
Got1
Glutamate oxaloacetate transaminase 1 (Got1) encodes an L-aspartate:2-oxoglutarate aminotransferase involved in glutamate biosynthesis.
  
 
 0.961
Got2
Aspartate aminotransferase; Glutamate oxaloacetate transaminase 2 (Got2) encodes an L-aspartate:2-oxoglutarate aminotransferase involved in glutamate biosynthesis, which in turn regulates postsynaptic receptor field size.
  
 
 0.954
beta4GalNAcTB
beta1,4-N-acetylgalactosaminyltransferase B (beta4GalNAcTB) encodes a Golgi glycosyltransferase that transfers N-acetylgalactosamine to N-acetylglucosamine residues of glycosphingolipids.
    
   0.951
Faa
Fumarylacetoacetase activity. It is involved in the biological process described with: L-phenylalanine catabolic process; homogentisate catabolic process; tyrosine catabolic process.
 
  
 0.944
Mccc2
Probable methylcrotonoyl-CoA carboxylase beta chain, mitochondrial; Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3- methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism (By similarity). Vital for adult survival.
  
  
 0.867
GstZ2
Probable maleylacetoacetate isomerase 2; Catalyzes the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid in vitro. Has no glutathione thioltransferase activity with 4-hydroxynonenal (4-HNE), adrenochrome, phenethyl isothiocyanate (PEITC), 5-hydroperoxyeicosatetraenoic acid ((5S)-HpETE), prostaglandin A2 (PGA2) or 2-hydroxyethyldisulfide (HED). Belongs to the GST superfamily. Zeta family.
  
  
 0.779
CG2034
Anon-i1 protein; It is involved in the biological process described with: tRNA wobble uridine modification.
    
   0.772
CG17249
LD14179p; It is involved in the biological process described with: mitotic cell cycle checkpoint.
      
 0.761
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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