STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Pdss2Decaprenyl diphosphate synthase subunit 2, isoform A; Prenyltransferase activity; trans-hexaprenyltranstransferase activity. It is involved in the biological process described with: isoprenoid biosynthetic process; ubiquinone biosynthetic process; Belongs to the FPP/GGPP synthase family. (448 aa)    
Predicted Functional Partners:
Coq2
4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate; Belongs to the UbiA prenyltransferase family.
  
 
 0.993
Coq6
Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.
  
 
 0.967
qm
Quemao, isoform A; Quemao (qm) encodes the ortholog of human geranylgeranyl pyrophosphate synthase (GGPS1), which catalyses protein prenylation and thereby facilitates membrane targeting of proteins. The qm product contributes to heart formation, germ cell migration, and maintenance of plasma membrane integrity in growing oocytes.
     
 0.960
Coq5
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2).
  
 
 0.960
Coq4
Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial; Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides.
   
  
 0.953
Coq8
Coenzyme Q8; Protein kinase activity; kinase activity. It is involved in the biological process described with: mitochondrial electron transport, ubiquinol to cytochrome c; ubiquinone biosynthetic process.
  
 
 0.952
qless
Qless, isoform A; Qless (qless) encodes a protein involved in the synthesis of the isoprenoid side chain of Coenzyme Q, a lipid component of the mitochondrial electron transport chain; Belongs to the FPP/GGPP synthase family.
  
 
0.952
CG10778
Alkyl transferase; Dehydrodolichyl diphosphate synthase activity; polyprenyltransferase activity. It is involved in the biological process described with: polyprenol biosynthetic process; Belongs to the UPP synthase family.
  
 
 0.937
Fpps
Farnesyl pyrophosphate synthase (Fpps) encodes a protein involved in germ cell migration; Belongs to the FPP/GGPP synthase family.
    
 0.933
CG17565
Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.
   
 0.932
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: medium (46%) [HD]