STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ICA69Islet cell autoantigen 69 kDa (ICA69) encodes a protein that belongs to the BAR (Bin-Amphiphysin-Rvs) family of proteins. It regulates ionotropic glutamate receptor clustering at the neuromuscular junctions and controls synapse morphogenesis through a pathway that involves Spectrin and the product of Rab2. (411 aa)    
Predicted Functional Partners:
PICK1
Membrane curvature sensor activity; phospholipid binding; protein kinase C binding; protein domain specific binding.
   
 
 0.929
Rab2
Rab2, isoform A; Rab2 (Rab2) encodes a protein that belongs to the Rab family of small Ras-like GTPases that regulate vesicle trafficking. Rab2 product contributes to the maturation and fusion of endosomes and autophagosomes with lysosomes.
    
 
 0.885
CG8230
Dymeclin; It is involved in the biological process described with: Golgi organization; Belongs to the dymeclin family.
      
 0.800
iPLA2-VIA
Calcium-independent phospholipase A2 VIA (iPLA2-VIA) encodes a protein that localizes to cytosol and mitochondria involved in repairing oxidized mitochondrial lipids, such as cardiolipin, and thus preventing cytochrome c release. It is partially responsible for cardiolipin depletion and monolysocardiolipin accumulation in Taz-deficient flies, which is a model of Barth syndrome.
 
      0.759
Syx6
Syntaxin 6, isoform E; SNARE binding; SNAP receptor activity.
      
 0.700
Vps50
Vacuolar protein sorting 50; It is involved in the biological process described with: endocytic recycling; retrograde transport, endosome to Golgi.
      
 0.683
Golgin104
Golgin 104; Rab GTPase binding.
      
 0.650
tbc
Uncharacterized protein, isoform C; Rab GTPase binding; GTPase activator activity. It is involved in the biological process described with: regulation of GTPase activity; intracellular protein transport; protein secretion; activation of GTPase activity.
   
 
 0.581
Amph
Amphiphysin, isoform A; Amphiphysin (Amph) encodes a BAR and SH3 domain containing protein that regulates muscle transverse tubule formation. It exhibits post-synaptic localization at the neuromuscular junction and its mutants show locomotion defects.
      
 0.561
Arfip
Arfaptin (Arfip) a protein that functions to tether the dynactin complex to the Golgi membrane in motor neurons. This function is required for normal synaptic growth during larval development.
      
 0.545
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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