STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
saSpermatocyte arrest (sa) encodes a testis binding protein associated factor involved in control of the male meiotic cycle, gene expression regulation, and spermatid differentiation. (275 aa)    
Predicted Functional Partners:
Taf12
TBP-associated factor 12 (Taf12) encodes a protein that forms part of the multisubunit basal transcription factor TFIID, and it is important for its stability. It forms a histone-like pair with Taf4. Taf12 is also an integral component of the Drosophila SAGA histone acetyltransferase complex.
   
 0.993
can
Cannonball (can) encodes a testis-specific TBP-associated factor essential for spermatogenesis. It is required for the normal level of expression of a large number of spermatogenesis genes and is strongly associated with the nucleolus in primary spermatocytes.
   
 0.990
Taf12L
TBP-associated factor 30kD subunit alpha-2; Protein heterodimerization activity. It is involved in the biological process described with: transcription initiation from RNA polymerase II promoter.
   
 0.990
nht
No hitter (nht) encodes a testis binding protein associated factor involved in tissue-specific transcription regulation and spermatogenesis.
   
 0.990
Taf5
Transcription initiation factor TFIID subunit 5; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. May play a role in helping to anchor Taf4 within the TFIID complex. May be involved in transducing signals from various transcriptional regulators to the RNA polymerase II transcription machinery; Belongs to the WD repeat TAF5 family.
    
 0.988
Taf7
Transcription initiation factor TFIID subunit 7; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.
    
 0.987
Taf1
Transcription initiation factor TFIID subunit 1; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Largest component and core scaffold of the complex. Contains N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle. Negative regulator of the TATA box-binding activity of Tbp.
    
 0.986
Tbp
TATA binding protein (Tbp) encodes a basal transcription factor required at most RNA Pol I and Pol II-transcribed genes. Traditionally thought to be recruited only to TATA box containing promoters, recent work shows that promoters with very weak TATA box consensus sequences also recruit the product of Tbp as a part of the multisubunit TFIID basal transcription factor or via the SAGA histone acetyltransferase complex.
    
 0.985
Taf2
TBP-associated factor 2 (Taf2) encodes a protein that forms part of the multisubunit basal transcription factor TFIID. Together with the product of Taf1, it binds the Initiator and/or the DPE core promoter elements.
    
 0.985
Taf11
TBP-associated factor 11 (Taf11) encodes a protein that forms part of the multisubunit basal transcription factor TFIID. It enhances RNA interference efficiency, organizing the assembly of the RISC loading complex.
    
 0.983
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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