STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tbc1d8-9GH16847p; Calcium ion binding; Rab GTPase binding; GTPase activator activity. It is involved in the biological process described with: regulation of GTPase activity; intracellular protein transport; activation of GTPase activity. (1291 aa)    
Predicted Functional Partners:
Rab30
Rab30, isoform A; Rab30 (Rab30) encodes a JNK transcriptional target. It is involved in JNK-mediated processes such as dorsal closure, embryonic head involution and thorax closure.
    
 
 0.758
Tbc1d15-17
TBC1 domain family member 15/17, isoform A; Rab GTPase binding; GTPase activator activity. It is involved in the biological process described with: activation of GTPase activity; intracellular protein transport; regulation of GTPase activity.
   
  
 0.735
Charon
LD04951p; Charon (Charon) encodes a nuclear chromatin associated protein that controls Rel-dependent innate immune response and functions as a regulator of antibacterial and antifungal immune defense. It mediates Parp-dependent transcriptional responses downstream of the innate immune pathway.
   
  
 0.669
CG5346
FI07970p; Dioxygenase activity. It is involved in the biological process described with: oxidation-reduction process; Belongs to the iron/ascorbate-dependent oxidoreductase family.
      
 0.669
Ero1L
Ero1-like protein; Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes pdi-1, the enzyme catalyzing protein disulfide formation, in order to allow pdi-1 to sustain additional rounds of disulfide formation. Following pdi reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell (By similarity); Belongs to the EROs family.
   
  
 0.665
CG17883
RE60063p; GTPase activator activity; Rab GTPase binding. It is involved in the biological process described with: regulation of GTPase activity; endoplasmic reticulum to Golgi vesicle-mediated transport.
   
  
 0.642
CG5745
LD44506p; Rab GTPase binding; GTPase activator activity. It is involved in the biological process described with: regulation of GTPase activity; intracellular protein transport; activation of GTPase activity.
      
0.632
Snapin
SNAPIN protein homolog; Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in pigment granule biogenesis. May participate in the coupling of lysosomes to microtubule plus-end-directed kinesin motor (By similarity).
     
 0.626
Vap33
VAMP-associated protein 33kDa, isoform B; VAMP-associated protein 33kDa (Vap33) encodes a protein that plays a conserved role in synaptic homeostasis. It controls a number of processes which depend on phosphoinositide levels, such as synaptic growth and axonal transport. It binds to the product of Sac1 to maintain normal levels of phosphoinositides and to the product of Dscam1 to affect its localization within axonal projections.
      
 0.607
Wdfy2
WD repeat and FYVE domain containing 2, isoform A; Protein kinase binding; metal ion binding.
      
 0.601
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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