STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ORMDLORM1-like protein; Negative regulator of sphingolipid synthesis. (154 aa)    
Predicted Functional Partners:
lace
Lace, isoform A; Lace (lace) encodes a serine C-palmitoyltransferase involved in sphingolipid biosynthesis.
    
 0.997
Spt-I
Pyridoxal phosphate binding; serine C-palmitoyltransferase activity. It is involved in the biological process described with: positive regulation of sphingolipid biosynthetic process; ceramide biosynthetic process; sphingosine biosynthetic process.
   
 0.997
CG34293
MIP14036p.
    
 0.923
Alas
Aminolevulinate synthase (Alas) encodes a mitochondrial enzyme involved in cuticle barrier formation and thought to have a role in Heme biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
    
 
 0.697
CG10361
FI03238p; Pyridoxal phosphate binding; glycine C-acetyltransferase activity. It is involved in the biological process described with: biosynthetic process; threonine catabolic process; cellular amino acid metabolic process.
   
 
 0.639
CG3907
GH07226p.
    
 
 0.635
Sac1
Sac1 phosphatase (Sac1) encodes a lipid phosphatase that dephosphorylates phosphatidylinositol 4-phosphate to generate phosphatidylinositol. It is involved in dorsal closure, Hedgehog signaling and axon guidance.
    
 
 0.574
schlank
Schlank, isoform A; Schlank (schlank) encodes a member of the Ceramide Synthases family involved in sphingolipid metabolism. It is essential for ceramide synthesis and modulates triacylglycerol levels and transcriptional expression of body fat metabolism regulators.
   
 
 0.566
CG5447
Uncharacterized protein, isoform B; Protein-cysteine S-palmitoyltransferase activity. It is involved in the biological process described with: Golgi to plasma membrane protein transport; peptidyl-L-cysteine S-palmitoylation; protein targeting to membrane.
   
 
 0.555
Cerk
Ceramide kinase (Cerk) encodes a protein that catalyzes phosphorylation of ceramide, helping to maintain ceramide levels, which in turn regulates photoreceptor structure and function. It is also a component of WntD signaling and mediates primordial germ cell migration.
   
  
 0.541
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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