STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
egProtein embryonic gonad; Eagle (eg) encodes a transcription factor of the nuclear hormone receptor subfamily O. Its roles include serotonergic differentiation (in combination with the product of hkb) and axonal pathfinding. (373 aa)    
Predicted Functional Partners:
Smr
Smrter, isoform G; It is involved in the biological process described with: wing disc development; regulation of mitotic cell cycle; negative regulation of transcription by RNA polymerase II; ovarian follicle cell development.
    
 
 0.749
Spn100A
Serpin 100A; Serine-type endopeptidase inhibitor activity. It is involved in the biological process described with: negative regulation of endopeptidase activity; multicellular organism reproduction; Belongs to the serpin family.
      
 0.606
Idi
Hydrolase activity; isopentenyl-diphosphate delta-isomerase activity. It is involved in the biological process described with: isoprenoid biosynthetic process; isopentenyl diphosphate biosynthetic process.
      
 0.523
tx
Helix-loop-helix protein delilah; Taxi (tx) encodes a transcription factor that affects cell adhesion by regulating the expression of mys. It is involved in the development of multiple organs and cell-types including tendon cells, chordotonal organs and the wing.
    
 
 0.476
kek2
Kekkon 2.
      
 0.424
hkb
Huckebein (hkb) is expressed in patches within the embryonic neuroectoderm and a subset of neuroblasts and their progeny, where it is required for proper neuronal specification and axon targeting. It is a terminal gap gene mediating the maternal terminal information at the posterior end of the blastoderm embryo.
   
 
 0.419
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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