STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CycHCyclin H homolog; Cyclin-dependent protein serine/threonine kinase regulator activity; RNA polymerase II CTD heptapeptide repeat kinase activity. It is involved in the biological process described with: regulation of cyclin-dependent protein serine/threonine kinase activity; transcription initiation from RNA polymerase II promoter; phosphorylation of RNA polymerase II C-terminal domain; regulation of transcription by RNA polymerase II; transcription by RNA polymerase II. (324 aa)    
Predicted Functional Partners:
Cdk7
Cyclin-dependent kinase 7 (Cdk7) encodes a serine/threonine protein kinase whose activity depends on the regulatory subunits encoded by CycH and Mat1. This trimeric Cdk complex activates other Cdks by phosphorylation in their T-loop and is called Cdk activating kinase (CAK). CAK can also be part of TFIIH, where the product of Cdk7 phosphorylates different transcription substrates (e.g. CTD of Pol II).
   
 0.999
Mat1
CDK-activating kinase assembly factor MAT1; Menage a trois 1 (Mat1) encodes a RING finger protein involved in the activation of the kinase encoded by Cdk7.
   
 0.999
Xpd
Xeroderma pigmentosum D (Xpd) encodes a DNA helicase that is a subunit of the basal transcription and DNA repair factor TFIIH.
   
 0.998
mrn
General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family.
   
 0.998
Tfb4
Transcription factor B4; RNA polymerase II CTD heptapeptide repeat kinase activity; DNA-dependent ATPase activity.
   
 0.998
hay
General transcription and DNA repair factor IIH helicase subunit XPB; ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of haywire/XPB/ERCC3, but not its helicase activity, is req [...]
   
 0.997
Ssl1
General transcription factor IIH subunit; Zinc ion binding; nucleic acid binding.
   
 0.997
Tfb1
General transcription factor IIH subunit 1; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFII [...]
   
 0.997
TfIIEalpha
Transcription factor IIEalpha (TfIIEalpha) encodes the large subunit of the RNA polymerase II general transcription factor TFIIE. The products of TfIIEalpha and TfIIEbeta are essential for transcription initiation in vitro acting with RNA polymerase II and the other general transcription factors.
   
 0.994
Cdk9
Positive transcription elongation factor b small subunit; Cyclin-dependent kinase 9 (Cdk9) encodes a cyclin dependent kinase that along with the product of CycT forms the positive transcription elongation factor, which is involved in RNA polymerase II elongation control.
   
 0.993
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: low (22%) [HD]