STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Xe7Xe7, isoform A; Xe7 (Xe7) encodes a protein that contributes to axon guidance and lateral inhibition. (783 aa)    
Predicted Functional Partners:
mRpL30
Mitochondrial ribosomal protein L30; Structural constituent of ribosome. It is involved in the biological process described with: mitochondrial translation; translation.
      
 0.627
POSH
Plenty of SH3s (POSH) encodes a scaffold protein that regulates TNF-JNK signaling pathway.
      
 0.627
CG5116
FI04601p; Ribosome binding; GTP binding.
   
  
 0.625
Evi5
Ecotropic viral integration site 5 ortholog; Functions as a GTPase-activating protein (GAP). During border cell migration in the ovary, acts as a GAP for Rab11 and is necessary for the maintenance of active receptor tyrosine kinases at the leading edge.
      
 0.608
CG42255
Uncharacterized protein; Calcium ion binding.
      
 0.604
CG9515
Uncharacterized protein, isoform A; Nucleoside-triphosphate diphosphatase activity.
      
 0.602
Cubn
Cubilin homolog; Required in the nephrocyte for normal uptake of proteins and elimination of toxins, and for maintenance of endocytic trafficking structures. May function together with Amnionless.
      
 0.548
CG9773
Protein unc-50 homolog; May be required for cell surface expression of acetylcholine receptors; Belongs to the unc-50 family.
      
 0.531
sbb
Scribbler, isoform J; Scribbler (sbb) encodes a transcriptional co-regulator that acts mainly as a co-repressor. It interacts physically and genetically with the product of Gug and is used by the repressor encoded by tll in early embryos. It regulates larval behavior, photoreceptor axon target choice, and functions downstream of Hedgehog signaling.
   
  
 0.497
Psc
Polycomb group protein Psc; Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. Component of the PcG multiprotein PRC1 complex, a complex that acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-118', rendering chromatin heritably changed in its expressibility. Needed to maintain e [...]
   
 
 0.481
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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