node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CG14220 | CG3815 | FBpp0297991 | FBpp0070864 | FI07430p; Histone deacetylase activity; histone deacetylase binding. It is involved in the biological process described with: histone deacetylation; negative regulation of transcription by RNA polymerase II. | GH06635p; Transcription coregulator activity. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated. | 0.982 |
CG14220 | Caf1-55 | FBpp0297991 | FBpp0082511 | FI07430p; Histone deacetylase activity; histone deacetylase binding. It is involved in the biological process described with: histone deacetylation; negative regulation of transcription by RNA polymerase II. | Probable histone-binding protein Caf1; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the nucleosome remodeling and deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylati [...] | 0.992 |
CG14220 | HDAC3 | FBpp0297991 | FBpp0078414 | FI07430p; Histone deacetylase activity; histone deacetylase binding. It is involved in the biological process described with: histone deacetylation; negative regulation of transcription by RNA polymerase II. | Histone deacetylase 3 (HDAC3) encodes a histone deacetylase involved in chromatin silencing. It controls cell growth through apoptosis suppression by regulating transcription of hid; Belongs to the histone deacetylase family. HD Type 1 subfamily. | 0.887 |
CG14220 | HDAC4 | FBpp0297991 | FBpp0305523 | FI07430p; Histone deacetylase activity; histone deacetylase binding. It is involved in the biological process described with: histone deacetylation; negative regulation of transcription by RNA polymerase II. | Histone deacetylase 4, isoform G; Histone deacetylase 4 (HDAC4) encodes a Class IIa histone deacetylase that modulates gene expression by associating with transcriptional factors. It is regulated by nucleocytoplasmic shuttling and contributes to embryogenesis, muscle development, circadian function, energy balance and memory. | 0.485 |
CG14220 | MBD-R2 | FBpp0297991 | FBpp0082081 | FI07430p; Histone deacetylase activity; histone deacetylase binding. It is involved in the biological process described with: histone deacetylation; negative regulation of transcription by RNA polymerase II. | MBD-R2 (MBD-R2) encodes a Zinc finger C2H2 transcription factor. It is a component of nonspecific lethal (NSL) complex involved in transcriptional activation. | 0.851 |
CG14220 | MRG15 | FBpp0297991 | FBpp0306049 | FI07430p; Histone deacetylase activity; histone deacetylase binding. It is involved in the biological process described with: histone deacetylation; negative regulation of transcription by RNA polymerase II. | NuA4 complex subunit EAF3 homolog; Part of the Tip60 chromatin-remodeling complex which is involved in DNA repair. Upon induction of DNA double-strand breaks, this complex acetylates phosphorylated H2AV in nucleosomes and exchanges it with unmodified H2AV. | 0.849 |
CG14220 | Sin3A | FBpp0297991 | FBpp0293225 | FI07430p; Histone deacetylase activity; histone deacetylase binding. It is involved in the biological process described with: histone deacetylation; negative regulation of transcription by RNA polymerase II. | Sin3A, isoform G; Sin3A (Sin3A) encodes a chromatin regulator with roles during muscle development, cell migration and Wnt signalling regulation. | 0.999 |
CG17002 | HDAC3 | FBpp0085502 | FBpp0078414 | LD41464p. | Histone deacetylase 3 (HDAC3) encodes a histone deacetylase involved in chromatin silencing. It controls cell growth through apoptosis suppression by regulating transcription of hid; Belongs to the histone deacetylase family. HD Type 1 subfamily. | 0.827 |
CG17002 | Smr | FBpp0085502 | FBpp0305909 | LD41464p. | Smrter, isoform G; It is involved in the biological process described with: wing disc development; regulation of mitotic cell cycle; negative regulation of transcription by RNA polymerase II; ovarian follicle cell development. | 0.886 |
CG17002 | ebi | FBpp0085502 | FBpp0077715 | LD41464p. | F-box-like/WD repeat-containing protein ebi; F-box-like component of E3 ubiquitin ligase complexes; involved in R7 photoreceptor cell differentiation, cone cell development and neuronal cell cycle control. E3 ubiquitin ligase complexes mediate ubiquitination and subsequent proteasomal degradation of target proteins. Required for specification of R7 photoreceptor cell fate in the eye by participating in the ubiquitination and subsequent proteasomal degradation of Tramtrack (ttk), a general inhibitor of photoreceptor differentiation. Required to block the S phase entry in the peripheral [...] | 0.912 |
CG3815 | CG14220 | FBpp0070864 | FBpp0297991 | GH06635p; Transcription coregulator activity. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated. | FI07430p; Histone deacetylase activity; histone deacetylase binding. It is involved in the biological process described with: histone deacetylation; negative regulation of transcription by RNA polymerase II. | 0.982 |
CG3815 | Caf1-55 | FBpp0070864 | FBpp0082511 | GH06635p; Transcription coregulator activity. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated. | Probable histone-binding protein Caf1; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the nucleosome remodeling and deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylati [...] | 0.996 |
CG3815 | HDAC3 | FBpp0070864 | FBpp0078414 | GH06635p; Transcription coregulator activity. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated. | Histone deacetylase 3 (HDAC3) encodes a histone deacetylase involved in chromatin silencing. It controls cell growth through apoptosis suppression by regulating transcription of hid; Belongs to the histone deacetylase family. HD Type 1 subfamily. | 0.824 |
CG3815 | HDAC4 | FBpp0070864 | FBpp0305523 | GH06635p; Transcription coregulator activity. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated. | Histone deacetylase 4, isoform G; Histone deacetylase 4 (HDAC4) encodes a Class IIa histone deacetylase that modulates gene expression by associating with transcriptional factors. It is regulated by nucleocytoplasmic shuttling and contributes to embryogenesis, muscle development, circadian function, energy balance and memory. | 0.588 |
CG3815 | MBD-R2 | FBpp0070864 | FBpp0082081 | GH06635p; Transcription coregulator activity. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated. | MBD-R2 (MBD-R2) encodes a Zinc finger C2H2 transcription factor. It is a component of nonspecific lethal (NSL) complex involved in transcriptional activation. | 0.631 |
CG3815 | MRG15 | FBpp0070864 | FBpp0306049 | GH06635p; Transcription coregulator activity. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated. | NuA4 complex subunit EAF3 homolog; Part of the Tip60 chromatin-remodeling complex which is involved in DNA repair. Upon induction of DNA double-strand breaks, this complex acetylates phosphorylated H2AV in nucleosomes and exchanges it with unmodified H2AV. | 0.995 |
CG3815 | Sin3A | FBpp0070864 | FBpp0293225 | GH06635p; Transcription coregulator activity. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated. | Sin3A, isoform G; Sin3A (Sin3A) encodes a chromatin regulator with roles during muscle development, cell migration and Wnt signalling regulation. | 0.998 |
Caf1-55 | CG14220 | FBpp0082511 | FBpp0297991 | Probable histone-binding protein Caf1; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the nucleosome remodeling and deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylati [...] | FI07430p; Histone deacetylase activity; histone deacetylase binding. It is involved in the biological process described with: histone deacetylation; negative regulation of transcription by RNA polymerase II. | 0.992 |
Caf1-55 | CG3815 | FBpp0082511 | FBpp0070864 | Probable histone-binding protein Caf1; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the nucleosome remodeling and deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylati [...] | GH06635p; Transcription coregulator activity. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated. | 0.996 |
Caf1-55 | HDAC3 | FBpp0082511 | FBpp0078414 | Probable histone-binding protein Caf1; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the nucleosome remodeling and deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylati [...] | Histone deacetylase 3 (HDAC3) encodes a histone deacetylase involved in chromatin silencing. It controls cell growth through apoptosis suppression by regulating transcription of hid; Belongs to the histone deacetylase family. HD Type 1 subfamily. | 0.922 |