STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
obst-EProtein obstructor-E; Chitin-binding protein that is important for the longitudinal contraction and lateral expansion of the larval cuticle during its conversion into the oval-shaped puparium case. Essential for survival to the second instar larval stage. Confers the orientated contractility and expandability of the larval cuticle by regulating the arrangement of chitin and the formation of supracellular ridges on the cuticle of third instar larvae. Essential for determining pupal body shape; required for the orientated shape change of the cuticle during metamorphosis which involves ch [...] (249 aa)    
Predicted Functional Partners:
TwdlD
RE49895p; TweedleD (TwdlD) encodes a chitin-binding protein that is a member of the Tweedle family of cuticle proteins.
   
  
 0.844
Cpr67B
Cuticular protein 67B; Structural constituent of cuticle; structural constituent of chitin-based larval cuticle. It is involved in the biological process described with: chitin-based cuticle development.
   
 
 0.826
slf
C-type lectin 27kD, isoform A; Schlaff (slf) encodes a chitin binding protein involved in wing formation and the substrate for the product of Tg.
   
  
 0.760
verm
Vermiform, isoform I; Vermiform (verm) encodes a chitin deacetylase-like protein that is secreted by tracheal cells and accumulates in the embryonic tracheal lumen. Its functions include cuticle development and tracheal tube size control.
  
  
 0.678
resilin
Pro-resilin; Plays a central role in insect flight by providing low stiffness, high strain and efficient energy storage.
      
 0.671
Cpr67Fa1
Cuticular protein 67Fa1; Structural constituent of cuticle; structural constituent of chitin-based larval cuticle. It is involved in the biological process described with: chitin-based cuticle development.
   
  
 0.666
TwdlF
LD19715p; Structural constituent of chitin-based larval cuticle. It is involved in the biological process described with: chitin-based cuticle development.
   
 
 0.636
TwdlS
RT12701p1; Structural constituent of chitin-based cuticle. It is involved in the biological process described with: body morphogenesis; chitin-based cuticle development.
      
 0.607
serp
Serpentine, isoform B; Serpentine (serp) encodes a putative chitin deacetylase. It is expressed by the epidermal and tracheal cells and is secreted into the apical extracellular space. Its activity maintains the strength of cuticles and restricts tracheal tube length.
  
  
 0.548
l(2)34Fc
Defense protein l(2)34Fc; May have antimicrobial activity. A late response immune regulated gene that is negatively regulated by spz during the immune response; Belongs to the insect defense protein family.
   
    0.544
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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