STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tango1Transport and Golgi organization protein 1; Required for protein secretion. May participate in cargo loading by binding to COPII coat subunits and guiding SH3-bound proteins into a growing carrier. At basal transitional ER sites in follicle epithelial cells, mediates the exit of basal membrane protein such as vkg, LanB1 and Trol, from the endoplasmic reticulum (ER) to basal Golgi clusters. (1430 aa)    
Predicted Functional Partners:
CG9175
FI09914p; GTPase activator activity; Sar guanyl-nucleotide exchange factor activity; GTPase binding. It is involved in the biological process described with: cell morphogenesis; regulation of COPII vesicle coating; protein secretion.
   
 0.994
Sec23
Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily.
   
 
 0.959
Sec31
Secretory 31 (Sec31) encodes a protein involved in the innate immune response.
   
 
 0.926
Sar1
Secretion-associated Ras-related 1 (Sar1) encodes a small GTPase that is recruited to the endoplasmic reticulum and initiates the recruitment of the COPII subunit complex Sec23/Sec24.
    
 
 0.891
Sec13
Protein SEC13 homolog; Functions as a component of the nuclear pore complex (NPC) and the COPII coat (By similarity). At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles (By similarity). Recruited to transcriptionally active chromatin at the time of transcription initiation by RNA polymerase II. Required for proper expression of ecdysone-responsive genes such as Eip74EF and Eip75B during larval development. Required for reactivation of transcription after heat shock. Required for nuclear import of phosphorylated Mad via importin msk. Has no role i [...]
   
 
 0.882
Sec16
Secretory 16 (Sec16) encodes a protein involved in the organization of endoplasmic reticulum exit sites. It contributes to stress response to amino-acid starvation, during which it mediates the formation of both Sec bodies and stress granules.
   
 
 0.857
ergic53
Ergic53, isoform A; Mannose binding. It is involved in the biological process described with: endoplasmic reticulum to Golgi vesicle-mediated transport; endoplasmic reticulum organization; Golgi organization.
   
 
 0.856
GM130
Golgi matrix protein 130 kD (GM130) encodes a protein involved in Golgi compartmental organization and regulation of dendrite morphogenesis.
   
 
 0.754
Pgant4
N-acetylgalactosaminyltransferase 4; Glycopeptide transferase involved in O-linked oligosaccharide biosynthesis, which catalyzes the transfer of an N-acetyl-D- galactosamine residue to an already glycosylated peptide. In contrast to other proteins of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on the protein receptor, but instead requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties. Some peptide transferase activity is however not excluded, considering that its appropriate peptide s [...]
    
 
 0.729
Tmem131
Transmembrane protein 131 homolog.
   
  
 0.708
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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