STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Rat1Rat1 5'-3' exoribonuclease (Rat1) encodes a member of the 5'-3' exonuclease family. It is required for mRNA processing and mutations cause phenotypes in various cell types, including the nervous system. (908 aa)    
Predicted Functional Partners:
Rai1
Decapping nuclease DXO homolog; Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping and pyrophosphohydrolase activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5' end triphosphate to release pyrophosphates (By similarity). Belongs to the DXO/Dom3Z family.
   
 
 0.990
pcm
5'-3' exoribonuclease 1; Pacman (pcm) encodes an exoribonuclease that degrades decapped mRNA. It is involved in epithelial closure, male fertility, apoptosis and growth control.
  
 
0.985
cuff
Cutoff (cuff) encodes a protein that interacts with the products of rhi and del in a germline complex that allows noncanonical transcription of dual-strand piRNA clusters. The product of cuff is therefore an integral part of the piRNA response to transposon activity in the germline. In its absence, a DNA damage checkpoint is activated leading to ventralization of the egg and embryo.
   
 
 0.951
CG9018
Uncharacterized protein, isoform A; RNA polymerase II complex binding. It is involved in the biological process described with: mRNA 3'-end processing.
   
 
 0.930
CG5964
Uncharacterized protein; It is involved in the biological process described with: cilium assembly; establishment of epithelial cell polarity.
    
 
 0.929
Rrp6
Rrp6, isoform B; Rrp6 (Rrp6) encodes an exoribonuclease that forms part of the RNA processing exosome complex. It is involved in the regulation of cell cycle progresion and mRNA surveillance.
   
 
 0.891
Pcf11
Protein 1 of cleavage and polyadenylation factor 1 (Pcf11) encodes an RNA binding protein involved in RNA splicing regulation.
    
 
 0.881
Dis3
Dis3, isoform A; Dis3 (Dis3) encodes an exoribonuclease that forms part of the RNA processing exosome complex. It is involved in the regulation of cell cycle progresion, microRNA expression and mRNA surveillance; Belongs to the RNR ribonuclease family.
   
  
 0.874
Mtr4
Mtr4 helicase (Mtr4) encodes an RNA helicase involved in the viral defense response.
   
 
 0.868
CG15160
Uncharacterized protein, isoform C; RNA polymerase II complex binding. It is involved in the biological process described with: mRNA 3'-end processing.
   
 
 0.833
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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