| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Aos1 | CG32110 | FBpp0082065 | FBpp0075663 | Activator of SUMO 1 (Aos1) encodes one of two subunits (along with the product of Uba2) of the heterodimeric SUMO activating enzyme. | ULP_PROTEASE domain-containing protein; SUMO-specific isopeptidase activity. It is involved in the biological process described with: protein desumoylation. | 0.705 |
| Aos1 | Nedd8 | FBpp0082065 | FBpp0309711 | Activator of SUMO 1 (Aos1) encodes one of two subunits (along with the product of Uba2) of the heterodimeric SUMO activating enzyme. | NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control, embryogenesis and neurogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex Uba3-Ula1 and linkage to the E2 enzyme UbcE2M. Attachment of Nedd8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins. | 0.812 |
| Aos1 | RanGAP | FBpp0082065 | FBpp0080775 | Activator of SUMO 1 (Aos1) encodes one of two subunits (along with the product of Uba2) of the heterodimeric SUMO activating enzyme. | Ran GTPase-activating protein; GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state (By similarity). Trans-acting factor necessary for meiotic distortion. Distortion is only seen in individuals that carry the RanGAP tandem duplication and express a RanGAP truncated protein. Binding of truncated RanGAP product to the Responder(RSP) locus initiates events that lead to sperm dysfunction. During oogenesis, plays a role in the biogenesis of annulate lamellae containing nuclear pore complex components. Belongs to the RN [...] | 0.838 |
| Aos1 | Su(var)2-10 | FBpp0082065 | FBpp0087651 | Activator of SUMO 1 (Aos1) encodes one of two subunits (along with the product of Uba2) of the heterodimeric SUMO activating enzyme. | Suppressor of variegation 2-10 (Su(var)2-10) encodes a member of the PIAS protein family that regulates chromosome structure and function. As a JAK/STAT pathway regulator, it contributes to eye formation and eye determination. | 0.967 |
| Aos1 | Uba2 | FBpp0082065 | FBpp0076457 | Activator of SUMO 1 (Aos1) encodes one of two subunits (along with the product of Uba2) of the heterodimeric SUMO activating enzyme. | SUMO-activating enzyme subunit; Ubiquitin-like activating enzyme 2 (Uba2) encodes one of two subunits (along with the product of Aos1) of the heterodimeric SUMO activating enzyme. It contains the catalytic cysteine residue that first becomes adenylated using ATP and that then forms a thioester linkage to the C-terminal end of SUMO; Belongs to the ubiquitin-activating E1 family. | 0.999 |
| Aos1 | Ulp1 | FBpp0082065 | FBpp0074462 | Activator of SUMO 1 (Aos1) encodes one of two subunits (along with the product of Uba2) of the heterodimeric SUMO activating enzyme. | GH15225p; Ulp1 (Ulp1) encodes a cysteine protease that catalyzes both SUMO maturation and SUMO deconjugation. It localizes to the nucleoplasmic face of the nuclear pore complex. Ulp1 knockdown in S2 cells results in relocalization of SUMO from the nucleus to the cytoplasm. | 0.843 |
| Aos1 | dgrn | FBpp0082065 | FBpp0078287 | Activator of SUMO 1 (Aos1) encodes one of two subunits (along with the product of Uba2) of the heterodimeric SUMO activating enzyme. | Degringolade, isoform A; Degringolade (dgrn) encodes a SUMO-Targeted ubiquitin ligase. During development it is required for Notch signaling and patterning. It contributes to transcriptional regulation, DNA repair, and cytoskeleton dynamics. | 0.726 |
| Aos1 | lwr | FBpp0082065 | FBpp0301731 | Activator of SUMO 1 (Aos1) encodes one of two subunits (along with the product of Uba2) of the heterodimeric SUMO activating enzyme. | Lesswright (lwr) encodes Ubc9, a SUMO conjugating enzyme that accepts SUMO from the SUMO activating enzyme and hands it off to the SUMO conjugation target. It has documented biological functions in innate immunity, meiosis, and anterior patterning of the embryo. | 0.999 |
| Aos1 | smt3 | FBpp0082065 | FBpp0078984 | Activator of SUMO 1 (Aos1) encodes one of two subunits (along with the product of Uba2) of the heterodimeric SUMO activating enzyme. | Small ubiquitin-related modifier; Smt3 (smt3) encodes the only Drosophila SUMO family protein. It is required for embryonic patterning and mitosis. It may also have roles in wing patterning, Dpp signaling, and Ras/MAPK signaling. It localizes to the nucleus during interphase and to the kinetochores and midbodies during mitosis; Belongs to the ubiquitin family. SUMO subfamily. | 0.999 |
| CG32110 | Aos1 | FBpp0075663 | FBpp0082065 | ULP_PROTEASE domain-containing protein; SUMO-specific isopeptidase activity. It is involved in the biological process described with: protein desumoylation. | Activator of SUMO 1 (Aos1) encodes one of two subunits (along with the product of Uba2) of the heterodimeric SUMO activating enzyme. | 0.705 |
| CG32110 | RanGAP | FBpp0075663 | FBpp0080775 | ULP_PROTEASE domain-containing protein; SUMO-specific isopeptidase activity. It is involved in the biological process described with: protein desumoylation. | Ran GTPase-activating protein; GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state (By similarity). Trans-acting factor necessary for meiotic distortion. Distortion is only seen in individuals that carry the RanGAP tandem duplication and express a RanGAP truncated protein. Binding of truncated RanGAP product to the Responder(RSP) locus initiates events that lead to sperm dysfunction. During oogenesis, plays a role in the biogenesis of annulate lamellae containing nuclear pore complex components. Belongs to the RN [...] | 0.842 |
| CG32110 | SMC5 | FBpp0075663 | FBpp0290815 | ULP_PROTEASE domain-containing protein; SUMO-specific isopeptidase activity. It is involved in the biological process described with: protein desumoylation. | Structural maintenance of chromosomes 5 (SMC5) encodes a component of the SMC5/6 protein complex that is critical to genome stability and required for homologous DNA recombination-based processes. | 0.447 |
| CG32110 | Su(var)2-10 | FBpp0075663 | FBpp0087651 | ULP_PROTEASE domain-containing protein; SUMO-specific isopeptidase activity. It is involved in the biological process described with: protein desumoylation. | Suppressor of variegation 2-10 (Su(var)2-10) encodes a member of the PIAS protein family that regulates chromosome structure and function. As a JAK/STAT pathway regulator, it contributes to eye formation and eye determination. | 0.795 |
| CG32110 | Uba2 | FBpp0075663 | FBpp0076457 | ULP_PROTEASE domain-containing protein; SUMO-specific isopeptidase activity. It is involved in the biological process described with: protein desumoylation. | SUMO-activating enzyme subunit; Ubiquitin-like activating enzyme 2 (Uba2) encodes one of two subunits (along with the product of Aos1) of the heterodimeric SUMO activating enzyme. It contains the catalytic cysteine residue that first becomes adenylated using ATP and that then forms a thioester linkage to the C-terminal end of SUMO; Belongs to the ubiquitin-activating E1 family. | 0.577 |
| CG32110 | Ulp1 | FBpp0075663 | FBpp0074462 | ULP_PROTEASE domain-containing protein; SUMO-specific isopeptidase activity. It is involved in the biological process described with: protein desumoylation. | GH15225p; Ulp1 (Ulp1) encodes a cysteine protease that catalyzes both SUMO maturation and SUMO deconjugation. It localizes to the nucleoplasmic face of the nuclear pore complex. Ulp1 knockdown in S2 cells results in relocalization of SUMO from the nucleus to the cytoplasm. | 0.806 |
| CG32110 | lwr | FBpp0075663 | FBpp0301731 | ULP_PROTEASE domain-containing protein; SUMO-specific isopeptidase activity. It is involved in the biological process described with: protein desumoylation. | Lesswright (lwr) encodes Ubc9, a SUMO conjugating enzyme that accepts SUMO from the SUMO activating enzyme and hands it off to the SUMO conjugation target. It has documented biological functions in innate immunity, meiosis, and anterior patterning of the embryo. | 0.687 |
| CG32110 | smt3 | FBpp0075663 | FBpp0078984 | ULP_PROTEASE domain-containing protein; SUMO-specific isopeptidase activity. It is involved in the biological process described with: protein desumoylation. | Small ubiquitin-related modifier; Smt3 (smt3) encodes the only Drosophila SUMO family protein. It is required for embryonic patterning and mitosis. It may also have roles in wing patterning, Dpp signaling, and Ras/MAPK signaling. It localizes to the nucleus during interphase and to the kinetochores and midbodies during mitosis; Belongs to the ubiquitin family. SUMO subfamily. | 0.986 |
| Nedd8 | Aos1 | FBpp0309711 | FBpp0082065 | NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control, embryogenesis and neurogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex Uba3-Ula1 and linkage to the E2 enzyme UbcE2M. Attachment of Nedd8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins. | Activator of SUMO 1 (Aos1) encodes one of two subunits (along with the product of Uba2) of the heterodimeric SUMO activating enzyme. | 0.812 |
| Nedd8 | RanGAP | FBpp0309711 | FBpp0080775 | NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control, embryogenesis and neurogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex Uba3-Ula1 and linkage to the E2 enzyme UbcE2M. Attachment of Nedd8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins. | Ran GTPase-activating protein; GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state (By similarity). Trans-acting factor necessary for meiotic distortion. Distortion is only seen in individuals that carry the RanGAP tandem duplication and express a RanGAP truncated protein. Binding of truncated RanGAP product to the Responder(RSP) locus initiates events that lead to sperm dysfunction. During oogenesis, plays a role in the biogenesis of annulate lamellae containing nuclear pore complex components. Belongs to the RN [...] | 0.477 |
| Nedd8 | Uba2 | FBpp0309711 | FBpp0076457 | NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control, embryogenesis and neurogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex Uba3-Ula1 and linkage to the E2 enzyme UbcE2M. Attachment of Nedd8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins. | SUMO-activating enzyme subunit; Ubiquitin-like activating enzyme 2 (Uba2) encodes one of two subunits (along with the product of Aos1) of the heterodimeric SUMO activating enzyme. It contains the catalytic cysteine residue that first becomes adenylated using ATP and that then forms a thioester linkage to the C-terminal end of SUMO; Belongs to the ubiquitin-activating E1 family. | 0.835 |
