STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
nrv1Sodium/potassium-transporting ATPase subunit beta-1; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. (309 aa)    
Predicted Functional Partners:
Atpalpha
Sodium/potassium-transporting ATPase subunit alpha; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
   
 0.990
nrv2
Sodium/potassium-transporting ATPase subunit beta-2; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.
  
 
0.913
Mdr65
Multidrug resistance protein homolog 65; Multi drug resistance 65 (Mdr65) encodes a member of the MRP/ABCC subfamily of ATP-binding cassette (ABC) transporters. It is involved in humoral/CNS barrier drug exclusion and response to insecticide; Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
    
  0.901
JYalpha
Sodium/potassium-transporting ATPase subunit alpha; JYalpha (JYalpha) is a gene essential for male fertility as mutants produce immotile sperm.
   
 0.874
CG10226
Uncharacterized protein, isoform A; Efflux transmembrane transporter activity; ATP binding; ATPase-coupled transmembrane transporter activity; ATPase activity; ATPase-coupled xenobiotic transmembrane transporter activity. It is involved in the biological process described with: transmembrane transport; renal tubular secretion; response to toxic substance; xenobiotic transport.
    
 0.836
CG45062
Uncharacterized protein, isoform A; ATPase activity; nucleotide binding; calcium transmembrane transporter activity, phosphorylative mechanism; proton-exporting ATPase activity, phosphorylative mechanism. It is involved in the biological process described with: calcium ion transmembrane transport; cellular calcium ion homeostasis.
    
 0.831
Mdr50
Multi drug resistance 50; Efflux transmembrane transporter activity; ATPase-coupled xenobiotic transmembrane transporter activity; ATPase activity; ATPase-coupled transmembrane transporter activity; ATP binding. It is involved in the biological process described with: response to insecticide; response to toxic substance; xenobiotic transport; transmembrane transport; renal tubular secretion.
    
  0.724
Mdr49
Multidrug resistance protein homolog 49; Multi drug resistance 49 (Mdr49) encodes drug transmembrane transporter that belongs to the ABCB transporter subfamily and contributes to insecticide resistance.
    
  0.724
CG45063
Cation_ATPase_N domain-containing protein.
    
 
 0.657
CG13124
LP20791p; RNA binding; translation activator activity. It is involved in the biological process described with: regulation of translational initiation.
   
  
 0.615
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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