node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Brf | Taf1 | FBpp0082893 | FBpp0293442 | Brf, isoform A; Brf (Brf) encodes a transcription factor binding protein involved in transcription mediated by RNA polymerase III. | Transcription initiation factor TFIID subunit 1; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Largest component and core scaffold of the complex. Contains N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle. Negative regulator of the TATA box-binding activity of Tbp. | 0.445 |
Brf | TfIIB | FBpp0082893 | FBpp0305673 | Brf, isoform A; Brf (Brf) encodes a transcription factor binding protein involved in transcription mediated by RNA polymerase III. | Transcription factor IIB (TfIIB) encodes a basal transcription factor that binds to the TATA box-binding protein. It is required for the initiation of transcription by RNA polymerase II. | 0.862 |
Brf | Trf | FBpp0082893 | FBpp0079164 | Brf, isoform A; Brf (Brf) encodes a transcription factor binding protein involved in transcription mediated by RNA polymerase III. | TBP-related factor (Trf) is ubiquitiously expressed but upregulated in the central nervous system and the gonads of developing Drosophila. The majority of the product of Trf substitutes for the product of Tbp in Pol III transcription in complex with the product of Brf. The rest of the product of Trf initiates transcription of a small subset of PolII-transcribed genes regulating fly fertility and nervous system function. | 0.996 |
Taf1 | Brf | FBpp0293442 | FBpp0082893 | Transcription initiation factor TFIID subunit 1; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Largest component and core scaffold of the complex. Contains N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle. Negative regulator of the TATA box-binding activity of Tbp. | Brf, isoform A; Brf (Brf) encodes a transcription factor binding protein involved in transcription mediated by RNA polymerase III. | 0.445 |
Taf1 | Taf12 | FBpp0293442 | FBpp0081918 | Transcription initiation factor TFIID subunit 1; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Largest component and core scaffold of the complex. Contains N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle. Negative regulator of the TATA box-binding activity of Tbp. | TBP-associated factor 12 (Taf12) encodes a protein that forms part of the multisubunit basal transcription factor TFIID, and it is important for its stability. It forms a histone-like pair with Taf4. Taf12 is also an integral component of the Drosophila SAGA histone acetyltransferase complex. | 0.999 |
Taf1 | Taf13 | FBpp0293442 | FBpp0080872 | Transcription initiation factor TFIID subunit 1; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Largest component and core scaffold of the complex. Contains N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle. Negative regulator of the TATA box-binding activity of Tbp. | TBP-associated factor 13; DNA binding; protein heterodimerization activity; RNA polymerase II general transcription initiation factor activity; transcription coregulator activity. It is involved in the biological process described with: transcription initiation from RNA polymerase II promoter; regulation of transcription by RNA polymerase II. | 0.999 |
Taf1 | Taf2 | FBpp0293442 | FBpp0076090 | Transcription initiation factor TFIID subunit 1; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Largest component and core scaffold of the complex. Contains N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle. Negative regulator of the TATA box-binding activity of Tbp. | TBP-associated factor 2 (Taf2) encodes a protein that forms part of the multisubunit basal transcription factor TFIID. Together with the product of Taf1, it binds the Initiator and/or the DPE core promoter elements. | 0.999 |
Taf1 | Taf6 | FBpp0293442 | FBpp0074709 | Transcription initiation factor TFIID subunit 1; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Largest component and core scaffold of the complex. Contains N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle. Negative regulator of the TATA box-binding activity of Tbp. | TBP-associated factor 6 (Taf6) encodes a protein that forms part of the multisubunit basal transcription factor TFIID, and it might be important for its stability. It forms a histone-like pair with the product of e(y)1. It is required during all stages of development, but particularly during imaginal disc development and gametogenesis. | 0.999 |
Taf1 | Taf7 | FBpp0293442 | FBpp0081253 | Transcription initiation factor TFIID subunit 1; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Largest component and core scaffold of the complex. Contains N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle. Negative regulator of the TATA box-binding activity of Tbp. | Transcription initiation factor TFIID subunit 7; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. | 0.999 |
Taf1 | TfIIB | FBpp0293442 | FBpp0305673 | Transcription initiation factor TFIID subunit 1; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Largest component and core scaffold of the complex. Contains N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle. Negative regulator of the TATA box-binding activity of Tbp. | Transcription factor IIB (TfIIB) encodes a basal transcription factor that binds to the TATA box-binding protein. It is required for the initiation of transcription by RNA polymerase II. | 0.995 |
Taf1 | Trf | FBpp0293442 | FBpp0079164 | Transcription initiation factor TFIID subunit 1; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Largest component and core scaffold of the complex. Contains N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle. Negative regulator of the TATA box-binding activity of Tbp. | TBP-related factor (Trf) is ubiquitiously expressed but upregulated in the central nervous system and the gonads of developing Drosophila. The majority of the product of Trf substitutes for the product of Tbp in Pol III transcription in complex with the product of Brf. The rest of the product of Trf initiates transcription of a small subset of PolII-transcribed genes regulating fly fertility and nervous system function. | 0.982 |
Taf1 | bip2 | FBpp0293442 | FBpp0088179 | Transcription initiation factor TFIID subunit 1; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Largest component and core scaffold of the complex. Contains N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle. Negative regulator of the TATA box-binding activity of Tbp. | Bip2 (bip2) encodes a protein that interacts with the transcription factor encoded by Trl and is involved in transcriptional activation. | 0.999 |
Taf1 | e(y)1 | FBpp0293442 | FBpp0074237 | Transcription initiation factor TFIID subunit 1; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Largest component and core scaffold of the complex. Contains N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle. Negative regulator of the TATA box-binding activity of Tbp. | Transcription initiation factor TFIID subunit 9; Enhancer of yellow 1 (e(y)1) encodes a TAF9 protein and a main component of the Transcription factor II D (TFIID) complex. TFIID is involved in recruiting the transcription machinery to core promoters and organizing specific enhancer-promoter interactions. | 0.999 |
Taf12 | Taf1 | FBpp0081918 | FBpp0293442 | TBP-associated factor 12 (Taf12) encodes a protein that forms part of the multisubunit basal transcription factor TFIID, and it is important for its stability. It forms a histone-like pair with Taf4. Taf12 is also an integral component of the Drosophila SAGA histone acetyltransferase complex. | Transcription initiation factor TFIID subunit 1; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Largest component and core scaffold of the complex. Contains N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle. Negative regulator of the TATA box-binding activity of Tbp. | 0.999 |
Taf12 | Taf13 | FBpp0081918 | FBpp0080872 | TBP-associated factor 12 (Taf12) encodes a protein that forms part of the multisubunit basal transcription factor TFIID, and it is important for its stability. It forms a histone-like pair with Taf4. Taf12 is also an integral component of the Drosophila SAGA histone acetyltransferase complex. | TBP-associated factor 13; DNA binding; protein heterodimerization activity; RNA polymerase II general transcription initiation factor activity; transcription coregulator activity. It is involved in the biological process described with: transcription initiation from RNA polymerase II promoter; regulation of transcription by RNA polymerase II. | 0.999 |
Taf12 | Taf2 | FBpp0081918 | FBpp0076090 | TBP-associated factor 12 (Taf12) encodes a protein that forms part of the multisubunit basal transcription factor TFIID, and it is important for its stability. It forms a histone-like pair with Taf4. Taf12 is also an integral component of the Drosophila SAGA histone acetyltransferase complex. | TBP-associated factor 2 (Taf2) encodes a protein that forms part of the multisubunit basal transcription factor TFIID. Together with the product of Taf1, it binds the Initiator and/or the DPE core promoter elements. | 0.999 |
Taf12 | Taf6 | FBpp0081918 | FBpp0074709 | TBP-associated factor 12 (Taf12) encodes a protein that forms part of the multisubunit basal transcription factor TFIID, and it is important for its stability. It forms a histone-like pair with Taf4. Taf12 is also an integral component of the Drosophila SAGA histone acetyltransferase complex. | TBP-associated factor 6 (Taf6) encodes a protein that forms part of the multisubunit basal transcription factor TFIID, and it might be important for its stability. It forms a histone-like pair with the product of e(y)1. It is required during all stages of development, but particularly during imaginal disc development and gametogenesis. | 0.999 |
Taf12 | Taf7 | FBpp0081918 | FBpp0081253 | TBP-associated factor 12 (Taf12) encodes a protein that forms part of the multisubunit basal transcription factor TFIID, and it is important for its stability. It forms a histone-like pair with Taf4. Taf12 is also an integral component of the Drosophila SAGA histone acetyltransferase complex. | Transcription initiation factor TFIID subunit 7; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. | 0.999 |
Taf12 | TfIIB | FBpp0081918 | FBpp0305673 | TBP-associated factor 12 (Taf12) encodes a protein that forms part of the multisubunit basal transcription factor TFIID, and it is important for its stability. It forms a histone-like pair with Taf4. Taf12 is also an integral component of the Drosophila SAGA histone acetyltransferase complex. | Transcription factor IIB (TfIIB) encodes a basal transcription factor that binds to the TATA box-binding protein. It is required for the initiation of transcription by RNA polymerase II. | 0.964 |
Taf12 | Trf | FBpp0081918 | FBpp0079164 | TBP-associated factor 12 (Taf12) encodes a protein that forms part of the multisubunit basal transcription factor TFIID, and it is important for its stability. It forms a histone-like pair with Taf4. Taf12 is also an integral component of the Drosophila SAGA histone acetyltransferase complex. | TBP-related factor (Trf) is ubiquitiously expressed but upregulated in the central nervous system and the gonads of developing Drosophila. The majority of the product of Trf substitutes for the product of Tbp in Pol III transcription in complex with the product of Brf. The rest of the product of Trf initiates transcription of a small subset of PolII-transcribed genes regulating fly fertility and nervous system function. | 0.980 |