STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG7840Polyprenol reductase; Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N- glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism (By similarity). (326 aa)    
Predicted Functional Partners:
CG8311
Uncharacterized protein; Dolichol kinase activity. It is involved in the biological process described with: dolichyl monophosphate biosynthetic process.
   
 
 0.963
CG4593
CG4593-PA.
   
  
 0.862
CG15336
Uncharacterized protein; Sequence-specific DNA binding.
      
 0.839
CG11379
EG:BACR42I17.4 protein.
      
 0.839
CG15717
CG15717-PA; Oxidoreductase activity. It is involved in the biological process described with: oxidation-reduction process.
   
  
 0.838
Sclp
Sclp, isoform C; It is involved in the biological process described with: muscle system process.
      
 0.834
CG10853
CG10853-PA.
      
 0.795
CG9135
CG9135 protein; It is involved in the biological process described with: negative regulation of GTPase activity.
   
  
 0.698
CG16721
LD23868p; It is involved in the biological process described with: cAMP-mediated signaling; signal transduction.
      
 0.679
CG14717
CG14717 protein; Carboxylic ester hydrolase activity.
      
 0.671
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.