STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
Dh31Diuretic hormone class 2; Regulation of fluid secretion. Stimulates Malpighian tubules fluid secretion by activating the apical membrane V-ATPase via cyclic AMP of principal cells in the main secretory segment. (117 aa)    
Predicted Functional Partners:
Dh44
Diuretic hormone 44, isoform A; Hormone activity; G protein-coupled receptor binding; diuretic hormone activity; neuropeptide hormone activity. It is involved in the biological process described with: locomotor rhythm; G protein-coupled receptor signaling pathway; neuropeptide signaling pathway; body fluid secretion; hormone-mediated signaling pathway.
   
  
 0.850
Lk
Leucokinin (Lk) encodes a neuropeptide that regulates water balance and food intake. Three groups of leucokinergic neurons are identified in the brain and abdominal ganglion of larvae and adults. Serotonin and insulin peptides have receptors in the abdominal leucokinergic neurons.
   
  
 0.834
Capa
Cardio acceleratory peptide 2b; Capability (Capa) encodes three neuropeptides: two of the periviscerokinin family (CAPA-1 and CAPA-2) and one pyrokinin (pyrokinin-1) that activate the class A GPCRs encoded by CapaR and PK1-R respectively. Capa is expressed in neurosecretory cells innervating corpora cardiaca and abdomen. CAPA-1 and -2 act as diuretic hormones on the Malpighian tubules.
   
  
 0.689
sNPF
Short neuropeptide F precursor (sNPF) encodes a protein that binds to the product of sNPF-R and activates ERK-Dilps signaling or the PKA-CREB pathway. Its roles include the regulation of cell and organism growth, carbohydrate metabolism, lifespan, feeding behavior, locomotion, circadian rhythm, and sleep.
   
  
 0.634
Proc
Proctolin, isoform A; Proctolin (Proc) encodes a neuropeptide precursor protein that binds the product of Proc-R and is involved in heart rate regulation.
   
  
 0.619
Pdf
PDF precursor-related peptide; Pigment-dispersing factor (Pdf) encodes a secreted biologically active neuropeptide that acts via a specific G-protein-coupled receptor to trigger intracellular signaling. It has a prominent role in the physiology of circadian rhythms, as well as contributing to other processes such as control of flight and digestion.
    
 
 0.599
AstA
Allatostatin-A; May act as a neurotransmitter or neuromodulator.
   
  
 0.591
Dh44-R2
Diuretic hormone 44 receptor 2 (Dh44-R2) encodes a protein that exhibits diuretic hormone receptor activity. It is involved in G protein-coupled receptor signaling pathways, hormone-mediated signaling pathways, and response to salt stress.
      
 0.548
Lkr
Leucokinin receptor (Lkr) encodes a 7-transmembrane domain G-protein-coupled receptor (GPCR) with the product of Lk as a ligand. It signals through intracellular calcium, and is implicated in ion regulation by the Malpighian tubules and in feeding control.
      
 0.518
Mip
Allatostatins MIP; Ligand for the sex peptide receptor (SPR). Stabilizes sleep and maintains sleep homeostasis to inhibit the activity of wake-promoting circuits, such as those that involve the pigment dispersing factor (pdf) neurons. Regulated by the circadian clock network and pathways associated with a sleep homeostat. May also have a regulatory role in gut motility.
   
  
 0.510
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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