STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PrBPProbable cGMP 3',5'-cyclic phosphodiesterase subunit delta; 3',5'-cyclic-nucleotide phosphodiesterase activity; protein binding. It is involved in the biological process described with: mushroom body development; sensory perception of light stimulus. (151 aa)    
Predicted Functional Partners:
dnd
Dead end (dnd) encodes an Arf-like3 GTPase that controls the targeting of exocytosis machinery to specific apical domains in fusion cells during the tracheal branch fusion process.
   
 
 0.994
Arl2
ADP ribosylation factor-like 2 (Arl2) encodes a small GTPase within the ADP-ribosylation factor-like family. Arl2 product functions as a central regulator of microtubule growth and asymmetric division of neuroblasts.
   
 0.991
CG11811
GH06691p; Guanylate kinase activity. It is involved in the biological process described with: purine nucleotide metabolic process.
   
 
 0.907
CG5276
CG5276 protein; Nucleoside-diphosphatase activity; guanosine-diphosphatase activity; calcium ion binding; nucleoside-triphosphatase activity; uridine-diphosphatase activity. It is involved in the biological process described with: proteoglycan biosynthetic process.
     
  0.900
NTPase
NTPase, isoform F; Uridine-diphosphatase activity; guanosine-diphosphatase activity; Belongs to the GDA1/CD39 NTPase family.
     
  0.900
bur
Burgundy, isoform B; Burgundy (bur) encodes a GMP synthetase required for axon guidance. It regulates the activity of the ubiquitin protease encoded by Usp7.
     
  0.900
unc-119
Protein unc-119 homolog; Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization.
  
  
 0.863
CG3862
Uncharacterized protein.
    
 
 0.829
INPP5E
Inositol polyphosphate 5-phosphatase E; Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns-P2, and phosphatidylinositol 4,5-bisphosphate (PtdIns 4,5-P2) to phosphatidylinositol 4-phosphate (PI-4-P). By controlling the phosphoinositide composition of the cilia membrane of auditory receptor neurons, regulates the cilia localization of ktub and consequently the transient receptor potential channels iav and nompC. Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type IV family.
    
 
 0.802
CG34045
Uncharacterized protein.
    
 
 0.802
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.