STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Eaat1Excitatory amino acid transporter 1 (Eaat1) encodes a transmembrane protein with a glutamate:sodium symporter activity. It is regulated by Notch signalling and contributes to larval locomotion and lifespan. (479 aa)    
Predicted Functional Partners:
slif
Slimfast, isoform A; L-ornithine transmembrane transporter activity; L-lysine transmembrane transporter activity; arginine transmembrane transporter activity; basic amino acid transmembrane transporter activity; amino acid transmembrane transporter activity.
  
  
 0.852
RagA-B
Ras-related GTP binding A/B (RagA-B) encodes a Ras family GTPase that forms a heterodimer with the product of RagC-D. The heterodimer localizes on the lysosome surface and functions to relay amino acid signals to activate the product of Tor by recruiting it to the lysosome.
      
 0.834
Gs2
Glutamine synthetase 2 (Gs2) encodes an enzyme that converts glutamate to glutamine. It is expressed in the embryonic nervous system and regulates the size of glutamate neurotransmitter pools and synapse assembly.
   
  
 0.729
mnd
Minidiscs, isoform A; Minidiscs (mnd) encodes the putative amino acid/polyamine transporter involved in leucine import. It is expressed in the larval fat body and is required for the differentiation of the wing imaginal disc cells.
  
  
 0.725
Gs1
Glutamine synthetase 1 (Gs1) encodes the mitochondrial enzyme that uses glutamate and ammonia as substrates to synthesize glutamine, which is a precursor of purine and pyrimidine synthesis. An adequate level of maternally supplied Gs1 product activity is necessary in the early embryonic development. High level of glutamine in mitochondria causes megamitochondrial formation in cells.
   
  
 0.725
P5CS
Delta-1-pyrroline-5-carboxylate synthase; Glutamate-5-semialdehyde dehydrogenase activity; glutamate 5-kinase activity; delta1-pyrroline-5-carboxylate synthetase activity. It is involved in the biological process described with: oxidation-reduction process; proline biosynthetic process; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.
  
  
 0.725
JhI-21
Juvenile hormone Inducible-21, isoform A; L-amino acid transmembrane transporter activity. It is involved in the biological process described with: cellular response to leucine; defense response to fungus; L-leucine import across plasma membrane; positive regulation of insulin secretion; carbohydrate homeostasis.
  
  
 0.715
VGlut
Vesicular glutamate transporter, isoform A.
   
 
 0.696
VGAT
Vesicular GABA Transporter (VGAT) encodes an essential transporter that is responsible for packaging the neurotransmitter GABA into synaptic vesicles.
   
  
 0.689
alrm
Astrocytic leucine-rich repeat molecule.
   
  
 0.681
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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