STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hoipNHP2-like protein 1 homolog; Binds to the 5'-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding (By similarity); Belongs to the eukaryotic ribosomal protein eL8 family. (127 aa)    
Predicted Functional Partners:
CG3071
LD43561p; snoRNA binding. It is involved in the biological process described with: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); rRNA processing; positive regulation of transcription by RNA polymerase I.
   
 0.999
nop5
CG10206-PA; snoRNA binding. It is involved in the biological process described with: rRNA processing.
   
 0.999
Nop56
Nucleolar KKE/D repeat protein; snoRNA binding.
   
 0.999
U3-55K
U3 small nuclear riboprotein factor 55K; RNA binding; snoRNA binding; U3 snoRNA binding. It is involved in the biological process described with: rRNA processing.
   
 0.997
Fib
rRNA 2'-O-methyltransferase fibrillarin; S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of 'Gl [...]
   
 0.995
Prp31
Pre-mRNA processing factor 31 (Prp31) encodes a splicing factor associated with U4/U6.U5 tri-snRNP. It plays important roles in pre-mRNA splicing and other steps of RNA processing. Prp31 is essential for photoreceptor development.
   
 
 0.995
l(3)72Dn
Lethal (3) 72Dn, isoform B; It is involved in the biological process described with: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA).
   
 0.995
Prp3
Precursor RNA processing 3 (Prp3) encodes a protein that regulates chromatin silencing.
   
 
 0.994
RpS23
40S ribosomal protein S23; Structural constituent of ribosome. It is involved in the biological process described with: translation; cytoplasmic translation.
  
 0.993
RpS6
40S ribosomal protein S6; May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.
  
 0.992
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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