| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Als2 | Kap-alpha3 | FBpp0078116 | FBpp0081585 | Alsin homolog; Has guanine nucleotide exchange factor (GEF) activity towards Rab5. Promotes the exchange of GDP to GTP, converting inactive GDP- bound Rab5 into its active GTP-bound form. | Importin subunit alpha; Karyopherin alpha3 (Kap-alpha3) encodes a protein required for the nuclear import of the product of N; Belongs to the importin alpha family. | 0.700 |
| Als2 | Pen | FBpp0078116 | FBpp0079527 | Alsin homolog; Has guanine nucleotide exchange factor (GEF) activity towards Rab5. Promotes the exchange of GDP to GTP, converting inactive GDP- bound Rab5 into its active GTP-bound form. | Importin subunit alpha; Pendulin (Pen) encodes a member of the Importin-alpha protein family, an essential adaptor in the Ran-GTP nuclear transport cycle binding a cargo protein to the nuclear import receptor encoded by Fs(2)Ket. In addition to nuclear protein import, the product of Pen is involved in centrosome duplication, mitotic spindle dynamics, nuclear envelope assembly, ring canal formation in the female germline, geotaxic behaviour and perception of pain. | 0.700 |
| Cse1 | Fs(2)Ket | FBpp0080484 | FBpp0294037 | Exportin-2; Export receptor for importin alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates have been released into the nucleoplasm (By similarity). | Importin subunit beta; Required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. In Drosophila, may not function as a snRNP import receptor as it does not interact with components of the snRNP complex such as snRNP U1, U2, U4/U6 and Snup. | 0.946 |
| Cse1 | Kap-alpha3 | FBpp0080484 | FBpp0081585 | Exportin-2; Export receptor for importin alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates have been released into the nucleoplasm (By similarity). | Importin subunit alpha; Karyopherin alpha3 (Kap-alpha3) encodes a protein required for the nuclear import of the product of N; Belongs to the importin alpha family. | 0.908 |
| Cse1 | Nup153 | FBpp0080484 | FBpp0309144 | Exportin-2; Export receptor for importin alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates have been released into the nucleoplasm (By similarity). | Nuclear pore complex protein Nup153; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC. Essential for the nuclear import of nuclear localization signal (NLS)-containing proteins in a Importin alpha/Importin beta receptor-dependent manner. Required for nuclear import of Mad. Plays a role in chromosomal organization and gene expression regulation; stimulates transcription by promoting the formation of an open chromatin environment. Binds chromatin to nucleopor [...] | 0.730 |
| Cse1 | Nup358 | FBpp0080484 | FBpp0293235 | Exportin-2; Export receptor for importin alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates have been released into the nucleoplasm (By similarity). | E3 SUMO-protein ligase RanBP2; E3 SUMO-protein ligase (By similarity). Component of the nuclear pore complex (NPC), a complex required for trafficking across the nuclear envelope. Required for nuclear import of nuclear localization signal (NLS)-containing proteins in an importin alpha/importin beta-dependent manner, but also for the nuclear import of specific proteins such as phosphorylated Mad or the sesquiterpenoid juvenile hormone receptor Met as part of the juvenile hormone signal transduction pathway. Plays a role in nuclear mRNA export by recruiting the mRNA transport complex com [...] | 0.806 |
| Cse1 | Nup50 | FBpp0080484 | FBpp0087861 | Exportin-2; Export receptor for importin alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates have been released into the nucleoplasm (By similarity). | Nuclear pore complex protein Nup50; Component of the nuclear pore complex that has a direct role in nuclear protein import (By similarity). Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta- cargo complex and importin recycling (By similarity). Binds to transcriptionally active chromatin sites when located in the nucleoplasm and is involved in transcriptional activation. | 0.832 |
| Cse1 | Pen | FBpp0080484 | FBpp0079527 | Exportin-2; Export receptor for importin alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates have been released into the nucleoplasm (By similarity). | Importin subunit alpha; Pendulin (Pen) encodes a member of the Importin-alpha protein family, an essential adaptor in the Ran-GTP nuclear transport cycle binding a cargo protein to the nuclear import receptor encoded by Fs(2)Ket. In addition to nuclear protein import, the product of Pen is involved in centrosome duplication, mitotic spindle dynamics, nuclear envelope assembly, ring canal formation in the female germline, geotaxic behaviour and perception of pain. | 0.827 |
| Fs(2)Ket | Cse1 | FBpp0294037 | FBpp0080484 | Importin subunit beta; Required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. In Drosophila, may not function as a snRNP import receptor as it does not interact with components of the snRNP complex such as snRNP U1, U2, U4/U6 and Snup. | Exportin-2; Export receptor for importin alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates have been released into the nucleoplasm (By similarity). | 0.946 |
| Fs(2)Ket | Kap-alpha3 | FBpp0294037 | FBpp0081585 | Importin subunit beta; Required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. In Drosophila, may not function as a snRNP import receptor as it does not interact with components of the snRNP complex such as snRNP U1, U2, U4/U6 and Snup. | Importin subunit alpha; Karyopherin alpha3 (Kap-alpha3) encodes a protein required for the nuclear import of the product of N; Belongs to the importin alpha family. | 0.980 |
| Fs(2)Ket | Nup153 | FBpp0294037 | FBpp0309144 | Importin subunit beta; Required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. In Drosophila, may not function as a snRNP import receptor as it does not interact with components of the snRNP complex such as snRNP U1, U2, U4/U6 and Snup. | Nuclear pore complex protein Nup153; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC. Essential for the nuclear import of nuclear localization signal (NLS)-containing proteins in a Importin alpha/Importin beta receptor-dependent manner. Required for nuclear import of Mad. Plays a role in chromosomal organization and gene expression regulation; stimulates transcription by promoting the formation of an open chromatin environment. Binds chromatin to nucleopor [...] | 0.978 |
| Fs(2)Ket | Nup358 | FBpp0294037 | FBpp0293235 | Importin subunit beta; Required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. In Drosophila, may not function as a snRNP import receptor as it does not interact with components of the snRNP complex such as snRNP U1, U2, U4/U6 and Snup. | E3 SUMO-protein ligase RanBP2; E3 SUMO-protein ligase (By similarity). Component of the nuclear pore complex (NPC), a complex required for trafficking across the nuclear envelope. Required for nuclear import of nuclear localization signal (NLS)-containing proteins in an importin alpha/importin beta-dependent manner, but also for the nuclear import of specific proteins such as phosphorylated Mad or the sesquiterpenoid juvenile hormone receptor Met as part of the juvenile hormone signal transduction pathway. Plays a role in nuclear mRNA export by recruiting the mRNA transport complex com [...] | 0.995 |
| Fs(2)Ket | Nup50 | FBpp0294037 | FBpp0087861 | Importin subunit beta; Required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. In Drosophila, may not function as a snRNP import receptor as it does not interact with components of the snRNP complex such as snRNP U1, U2, U4/U6 and Snup. | Nuclear pore complex protein Nup50; Component of the nuclear pore complex that has a direct role in nuclear protein import (By similarity). Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta- cargo complex and importin recycling (By similarity). Binds to transcriptionally active chromatin sites when located in the nucleoplasm and is involved in transcriptional activation. | 0.975 |
| Fs(2)Ket | Pen | FBpp0294037 | FBpp0079527 | Importin subunit beta; Required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. In Drosophila, may not function as a snRNP import receptor as it does not interact with components of the snRNP complex such as snRNP U1, U2, U4/U6 and Snup. | Importin subunit alpha; Pendulin (Pen) encodes a member of the Importin-alpha protein family, an essential adaptor in the Ran-GTP nuclear transport cycle binding a cargo protein to the nuclear import receptor encoded by Fs(2)Ket. In addition to nuclear protein import, the product of Pen is involved in centrosome duplication, mitotic spindle dynamics, nuclear envelope assembly, ring canal formation in the female germline, geotaxic behaviour and perception of pain. | 0.981 |
| Kap-alpha3 | Als2 | FBpp0081585 | FBpp0078116 | Importin subunit alpha; Karyopherin alpha3 (Kap-alpha3) encodes a protein required for the nuclear import of the product of N; Belongs to the importin alpha family. | Alsin homolog; Has guanine nucleotide exchange factor (GEF) activity towards Rab5. Promotes the exchange of GDP to GTP, converting inactive GDP- bound Rab5 into its active GTP-bound form. | 0.700 |
| Kap-alpha3 | Cse1 | FBpp0081585 | FBpp0080484 | Importin subunit alpha; Karyopherin alpha3 (Kap-alpha3) encodes a protein required for the nuclear import of the product of N; Belongs to the importin alpha family. | Exportin-2; Export receptor for importin alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates have been released into the nucleoplasm (By similarity). | 0.908 |
| Kap-alpha3 | Fs(2)Ket | FBpp0081585 | FBpp0294037 | Importin subunit alpha; Karyopherin alpha3 (Kap-alpha3) encodes a protein required for the nuclear import of the product of N; Belongs to the importin alpha family. | Importin subunit beta; Required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. In Drosophila, may not function as a snRNP import receptor as it does not interact with components of the snRNP complex such as snRNP U1, U2, U4/U6 and Snup. | 0.980 |
| Kap-alpha3 | Nup153 | FBpp0081585 | FBpp0309144 | Importin subunit alpha; Karyopherin alpha3 (Kap-alpha3) encodes a protein required for the nuclear import of the product of N; Belongs to the importin alpha family. | Nuclear pore complex protein Nup153; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC. Essential for the nuclear import of nuclear localization signal (NLS)-containing proteins in a Importin alpha/Importin beta receptor-dependent manner. Required for nuclear import of Mad. Plays a role in chromosomal organization and gene expression regulation; stimulates transcription by promoting the formation of an open chromatin environment. Binds chromatin to nucleopor [...] | 0.922 |
| Kap-alpha3 | Nup358 | FBpp0081585 | FBpp0293235 | Importin subunit alpha; Karyopherin alpha3 (Kap-alpha3) encodes a protein required for the nuclear import of the product of N; Belongs to the importin alpha family. | E3 SUMO-protein ligase RanBP2; E3 SUMO-protein ligase (By similarity). Component of the nuclear pore complex (NPC), a complex required for trafficking across the nuclear envelope. Required for nuclear import of nuclear localization signal (NLS)-containing proteins in an importin alpha/importin beta-dependent manner, but also for the nuclear import of specific proteins such as phosphorylated Mad or the sesquiterpenoid juvenile hormone receptor Met as part of the juvenile hormone signal transduction pathway. Plays a role in nuclear mRNA export by recruiting the mRNA transport complex com [...] | 0.887 |
| Kap-alpha3 | Nup50 | FBpp0081585 | FBpp0087861 | Importin subunit alpha; Karyopherin alpha3 (Kap-alpha3) encodes a protein required for the nuclear import of the product of N; Belongs to the importin alpha family. | Nuclear pore complex protein Nup50; Component of the nuclear pore complex that has a direct role in nuclear protein import (By similarity). Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta- cargo complex and importin recycling (By similarity). Binds to transcriptionally active chromatin sites when located in the nucleoplasm and is involved in transcriptional activation. | 0.719 |
