STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
eEF1deltaProbable elongation factor 1-delta; EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP. (256 aa)    
Predicted Functional Partners:
eEF1gamma
Eukaryotic translation elongation factor 1 gamma (eEF1gamma) encodes a protein that associates with other EF1 subunits (alpha/beta/delta). It regulates organelle movement along microtubules. It binds tubulin and the protein kinase encoded by Doa, which in turns phosphorylates the product of eEF1gamma.
  
 0.999
eEF1beta
Probable elongation factor 1-beta; EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.
  
0.995
eEF1alpha2
Elongation factor 1-alpha 2; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
   
 0.986
eEF1alpha1
Elongation factor 1-alpha 1; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
   
 0.980
eEF5
Eukaryotic translation initiation factor 5A; mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis; Belongs to the eIF-5A family.
   
 
 0.947
RpS3A
Ribosomal protein S3A (RpS3A) encodes an essential component of the small ribosomal subunit that functions in protein synthesis. It is classified as a 'Minute' gene as heterozygous mutants exhibit a slower developmental rate and small adult bristles; Belongs to the eukaryotic ribosomal protein eS1 family.
   
 
 0.935
Tctp
Translationally controlled tumor protein (Tctp) encodes a protein that belongs to the TCTP family. It interacts with the GTPase encoded by Rheb to regulate organ growth. It is required for DNA damage response and genome stability.
  
 
 0.933
RpL35
Ribosomal protein L35, isoform A; mRNA binding; structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); translation.
  
 
 0.928
beta-PheRS
Phenylalanyl-tRNA synthetase, beta-subunit (beta-PheRS) encodes a cytoplasmic aminoacyl-tRNA synthetase that catalyzes the ligation of Phenylalanine to its cognate tRNAPhe. Together with the alpha-subunit it forms a tetrameric enzyme complex. This subunit plays a role in recognition and binding of tRNAPhe and it provides the editing site that hydrolyzes wrongfully activated or ligated compounds.
 
 
    0.923
RpL23
60S ribosomal protein L23; Large ribosomal subunit rRNA binding; structural constituent of ribosome; myosin binding. It is involved in the biological process described with: translation; cytoplasmic translation; Belongs to the universal ribosomal protein uL14 family.
  
 
 0.916
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.