Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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me31BATP-dependent RNA helicase me31b; ATP-dependent RNA helicase which is a core component of a variety of ribonucleoprotein complexes (RNPs) that play critical roles in translational repression and mRNA decapping during embryogenesis, oogenesis, neurogenesis and neurotransmission. Recruits core components and translational repressors to some RNP complexes, and mediates RNP aggregation into processing granules such as P-bodies. As part of a RNP complex containing tral, eIF4E1, cup, and pAbp, involved in RNP-mediated translational repression of maternal mRNAs during oogenesis and embryogene [...] (459 aa)    
Predicted Functional Partners:
LSm1
U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs.
   
 0.999
Edc3
Enhancer of mRNA-decapping protein 3; In the process of mRNA degradation, may play a role in mRNA decapping.
   
 0.999
LSm7
Like Sm 7, isoform A; RNA binding. It is involved in the biological process described with: nuclear-transcribed mRNA catabolic process; mRNA splicing, via spliceosome.
   
 0.999
tral
Trailer hitch (tral) encodes a protein required for oocyte dorsoventral patterning via actin and microtubule cytoskeleton organization.
   
 
 0.999
Patr-1
Protein associated with topo II related - 1 (Patr-1) encodes a P body component involved in mRNA decapping and regulation of synaptic growth at neuromuscular junctions.
   
 0.999
Ge-1
Enhancer of mRNA-decapping protein 4 homolog; In the process of mRNA degradation, seems to play a role in mRNA decapping. Required for silencing a subset of endogenous miRNA targets.
   
 0.998
cup
Protein cup; Adapter protein that plays a central role in localization of transcripts in the oocyte and in young embryos. Maintains RNA targets in a repressed state by promoting their deadenylation and protects deadenylated mRNAs from further degradation. Binds to and recruits eIF-4E to the 3'-UTR of some mRNA targets which prevents interaction between eIF4E1 and eIF4G. This may contribute to translational repression but does not appear to be necessary for it to occur. Can promote translational repression independently of deadenylation and eIF4E1 binding. Required for correct localizat [...]
  
 
 0.998
DCP1
Decapping protein 1 (DCP1) encodes a subunit of the mRNA decapping holoenzyme. It is involved in osk mRNA localization and miRNA-mediated gene silencing.
   
 0.997
pAbp
Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Since it interacts with the cap-associating translation initiation factor eIF4G, it is likely that it functions by linking Atx2 to the cap-binding complex. Forms a complex with tyf and Atx2 which functions in adult circadian pacemaker neurons to sustain circadian rhythms likely by switching between activator and repressor modes of post-transcriptional regulation via interaction with Lsm12a or me31B, respectively. The activator complex (Atx2-tyf activator complex) activates the TYF-dependent translation of per to maintain 24 [...]
   
 
 0.996
DCP2
Decapping protein 2 (DCP2) encodes a m7G(5')pppN diphosphatase involved in gene silencing by miRNA and the regulation of cytoplasmic mRNA processing body assembly.
   
 0.996
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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