STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
Nfs1Cysteine desulfurase, mitochondrial; Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe- S) clusters; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. (462 aa)    
Predicted Functional Partners:
bcn92
Protein bcn92; It is involved in the biological process described with: iron-sulfur cluster assembly; Belongs to the complex I LYR family.
   
 0.999
IscU
Iron-sulfur cluster assembly enzyme; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.
 
 0.999
fh
Frataxin homolog, mitochondrial; Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+). May be able to store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization. Required for ecdysteroidogenesis in the prothoracic gland which is necessary for larval to pupal transition. Belongs to the frataxin family.
   
 0.997
Uba4
Adenylyltransferase and sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln) (By similarity). Also essential during biosynthesis of the molybdenum cofactor (By similarity). Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (- COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus (By similarity). [...]
  
 0.984
Fdx2
Adrenodoxin-like protein 2, mitochondrial; Required for ecdysteroidogenesis in the prothoracic gland which is necessary for larval to pupal transition. Belongs to the adrenodoxin/putidaredoxin family.
  
 0.970
MagR
Iron-sulfur cluster assembly 1 homolog, mitochondrial; Involved in the assembly of mitochondrial iron-sulfur proteins. Probably involved in the binding of an intermediate of Fe/S cluster assembly (By similarity). Required for maintenance of circadian rhythms under constant darkness.
  
  
 0.963
CG8043
GH14121p; RNA binding. It is involved in the biological process described with: iron-sulfur cluster assembly.
   
  
 0.943
Fdx1
Adrenodoxin-like protein 1, mitochondrial; Required for ecdysteroidogenesis in the prothoracic gland which is necessary for larval to pupal transition. Belongs to the adrenodoxin/putidaredoxin family.
  
 0.943
CG13623
GEO08971p1; 2 iron, 2 sulfur cluster binding; structural molecule activity; 4 iron, 4 sulfur cluster binding; iron ion binding. It is involved in the biological process described with: protein maturation; protein maturation by [4Fe-4S] cluster transfer; iron-sulfur cluster assembly.
  
  
 0.941
CG12279
Thiosulfate sulfurtransferase activity.
  
 0.934
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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