STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
crokGEO12654p1; GPI anchor binding. It is involved in the biological process described with: septate junction assembly; sleep; positive regulation of voltage-gated potassium channel activity; regulation of tube size, open tracheal system; regulation of synaptic transmission, cholinergic. (151 aa)    
Predicted Functional Partners:
CG6583
GEO13220p1.
 
  
 0.968
crim
GEO04224p1; Crimpled (crim) encodes a protein involved in tracheal system development and the localization of septate junction components.
   
  
 0.883
udt
LD32918p; It is involved in the biological process described with: wound healing.
  
  
 0.882
kune
Kune-kune; It is involved in the biological process described with: establishment of glial blood-brain barrier; regulation of tube length, open tracheal system; septate junction assembly.
  
  
 0.819
bou
GEO07593p1; Boudin (bou) encodes a membrane glycoprotein of the Ly6 superfamily that is required for the formation of septate junctions in epithelial tissues.
   
  
 0.800
CG12880
LD29228p.
   
  
 0.799
CG31675
RE19849p.
      
 0.796
sinu
Sinuous (sinu) encodes a claudin that contributes to the assembly of septate junctions. It is involved in the development of heart, tracheal tree and the glial blood-brain barrier.
  
  
 0.760
Nrx-IV
Neurexin-4; Seems to play a role in the formation and function of septate junctions. Septate junctions, which are the equivalent of vertebrates tight junctions, are characterized by regular arrays of transverse structures that span the intermembrane space and form a physical barrier to diffusion. Required for the blood-brain barrier formation. Belongs to the neurexin family.
  
  
 0.693
CG9338
GEO04151p1.
      
 0.680
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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