Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
CG6180GH25425p. (257 aa)    
Predicted Functional Partners:
CG10672
SD02021p; Carbonyl reductase (NADPH) activity; 3-keto sterol reductase activity; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor.
  
 
 0.835
CG7924
LP03067p.
    
   0.809
CG43208
Uncharacterized protein.
    
   0.718
Raf
Raf homolog serine/threonine-protein kinase Raf; Serine/threonine kinase required in the early embryo for the formation of terminal structure. Also required during the proliferation of imaginal cells. May act downstream of Ras85D in the tor signal transduction pathway. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.
    
 0.678
mRpL44
Mitochondrial ribosomal protein L44; Ribonuclease III activity; double-stranded RNA binding; structural constituent of ribosome. It is involved in the biological process described with: RNA processing; primary miRNA processing; production of siRNA involved in RNA interference; mitochondrial translation; pre-miRNA processing.
   
 
 0.669
mRpL10
39S ribosomal protein L10, mitochondrial; Structural constituent of ribosome. It is involved in the biological process described with: ribosome biogenesis; mitochondrial translation; translation; Belongs to the universal ribosomal protein uL10 family.
   
 
 0.661
mRpL16
Mitochondrial ribosomal protein L16, isoform A; Structural constituent of ribosome; rRNA binding. It is involved in the biological process described with: mitochondrial translation.
   
 
 0.644
mRpS29
Mitochondrial ribosomal protein S29; Structural constituent of ribosome. It is involved in the biological process described with: mitochondrial translation; apoptotic process; translation.
   
 
 0.636
mRpS5
Mitochondrial ribosomal protein S5, isoform A; RNA binding; structural constituent of ribosome. It is involved in the biological process described with: translation; mitochondrial translation; Belongs to the universal ribosomal protein uS5 family.
   
   0.626
14-3-3zeta
14-3-3 protein zeta; Required in Raf-dependent cell proliferation and photoreceptor differentiation during eye development. Acts upstream of Raf and downstream of Ras, and is essential for viability. Acts as a negative regulator of the slo calcium channel via its interaction with slo-binding protein slob. Inhibits yki activity by restricting its nuclear localization. Binds to and promotes the activity of phosphoinositide 3-kinase Pi3K68D which converts phosphatidylinositol to phosphatidylinositol-3-phosphate and promotes maturation of early endosomes.
   
 0.623
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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