Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
CG16812LD36945p. (455 aa)    
Predicted Functional Partners:
CG5004
FI18040p1.
    
   0.831
kibra
Protein kibra; Regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. Kibra acts synergistically along with Ex and Mer to regulate the Hippo signalin [...]
    
   0.831
Hpr1
Hpr1 protein; It is involved in the biological process described with: mRNA export from nucleus in response to heat stress; mRNA export from nucleus; regulation of DNA-templated transcription, elongation; signal transduction.
    
   0.634
CG2926
Uncharacterized protein, isoform A; Zinc ion binding. It is involved in the biological process described with: regulation of alternative mRNA splicing, via spliceosome.
   
   0.566
mnb
Minibrain (mnb) encodes a Ser/Thr protein kinase of the DYRK subfamily. It interacts with several signaling pathways and it is involved in behavior, cell cycle, cytoskeleton dynamics, neural proliferation, neurogenesis, neuronal differentiation, synaptic plasticity, and tissue growth.
    
   0.457
fs(2)ltoPP43
Female sterile (2) ltoPP43, isoform A; It is involved in the biological process described with: developmental process; chorion-containing eggshell formation.
   
   0.433
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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