node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Atg12 | Atg14 | FBpp0289288 | FBpp0084739 | Autophagy protein 12-like; Required for autophagy. | Autophagy-related 14 (Atg14) encodes a protein involved in autophagy. | 0.977 |
Atg12 | Atg3 | FBpp0289288 | FBpp0074822 | Autophagy protein 12-like; Required for autophagy. | Autophagy-related 3 (Atg3) encodes a protein involved in multiple autophagy processes such as autophagosome assembly, cellular response to starvation, and glycophagy. | 0.999 |
Atg12 | Atg4a | FBpp0289288 | FBpp0077618 | Autophagy protein 12-like; Required for autophagy. | Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. | 0.972 |
Atg12 | Atg5 | FBpp0289288 | FBpp0071023 | Autophagy protein 12-like; Required for autophagy. | Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with Atg12, through a ubiquitin-like conjugating system involving Atg7 as an E1-like activating enzyme and Atg10 as an E2-like conjugating enzyme, is essential for its function. The Atg12-Atg5 conjugate acts as an E3- like enzyme which is required for lipidation of Atg8 and its association to the vesicle membranes (By similarity). | 0.999 |
Atg12 | Atg6 | FBpp0289288 | FBpp0083975 | Autophagy protein 12-like; Required for autophagy. | Beclin-1-like protein; Autophagy-related 6 (Atg6) encodes a component of the Vps34 complex that is required for the formation of PI3P, and functions in vesicle trafficking including autophagy and endocytosis. | 0.973 |
Atg12 | Debcl | FBpp0289288 | FBpp0085443 | Autophagy protein 12-like; Required for autophagy. | Death executioner Bcl-2 (Debcl) encodes a pro-apoptotic member of the Bcl-2 family involved in programmed cell death. | 0.963 |
Atg12 | Pi3K59F | FBpp0289288 | FBpp0071973 | Autophagy protein 12-like; Required for autophagy. | Phosphatidylinositol 3-kinase catalytic subunit type 3; Phosphotidylinositol 3 kinase 59F (Pi3K59F) encodes a lipid kinase that is required for formation of Phosphatidylinositol 3-phosphate. It functions in a core protein complex that includes the products of Atg6 and Vps15. It is involved in the control of vesicle trafficking, including autophagy, endocytosis and phagocytosis. | 0.989 |
Atg12 | Rubicon | FBpp0289288 | FBpp0304117 | Autophagy protein 12-like; Required for autophagy. | Uncharacterized protein, isoform A; Phosphatidylinositol phosphate binding. It is involved in the biological process described with: negative regulation of autophagy. | 0.533 |
Atg12 | Uvrag | FBpp0289288 | FBpp0080039 | Autophagy protein 12-like; Required for autophagy. | UV-resistance associated gene (Uvrag) encodes a protein that regulates autophagy and vesicle trafficking with the product of Atg6 and class C vacuolar protein sorting complexes. With the products of Atg6 and Pi3K59F, It forms a PI3K(III) complex and plays roles in receptor downregulation and the establishment of proper cell polarity. It is also critical for proper organ rotation during development by controlling receptor endocytosis and subsequent degradation. | 0.940 |
Atg12 | Vps15 | FBpp0289288 | FBpp0081466 | Autophagy protein 12-like; Required for autophagy. | Vacuolar protein sorting 15 (Vps15) encodes a serine/threonine protein kinase that is a core component of the Vps34/class III PI3-Kinase complex. It is required for the production of PI3P and influences multiple vesicle trafficking pathways, including autophagy and endocytosis. | 0.982 |
Atg14 | Atg12 | FBpp0084739 | FBpp0289288 | Autophagy-related 14 (Atg14) encodes a protein involved in autophagy. | Autophagy protein 12-like; Required for autophagy. | 0.977 |
Atg14 | Atg3 | FBpp0084739 | FBpp0074822 | Autophagy-related 14 (Atg14) encodes a protein involved in autophagy. | Autophagy-related 3 (Atg3) encodes a protein involved in multiple autophagy processes such as autophagosome assembly, cellular response to starvation, and glycophagy. | 0.949 |
Atg14 | Atg4a | FBpp0084739 | FBpp0077618 | Autophagy-related 14 (Atg14) encodes a protein involved in autophagy. | Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. | 0.936 |
Atg14 | Atg5 | FBpp0084739 | FBpp0071023 | Autophagy-related 14 (Atg14) encodes a protein involved in autophagy. | Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with Atg12, through a ubiquitin-like conjugating system involving Atg7 as an E1-like activating enzyme and Atg10 as an E2-like conjugating enzyme, is essential for its function. The Atg12-Atg5 conjugate acts as an E3- like enzyme which is required for lipidation of Atg8 and its association to the vesicle membranes (By similarity). | 0.977 |
Atg14 | Atg6 | FBpp0084739 | FBpp0083975 | Autophagy-related 14 (Atg14) encodes a protein involved in autophagy. | Beclin-1-like protein; Autophagy-related 6 (Atg6) encodes a component of the Vps34 complex that is required for the formation of PI3P, and functions in vesicle trafficking including autophagy and endocytosis. | 0.999 |
Atg14 | Debcl | FBpp0084739 | FBpp0085443 | Autophagy-related 14 (Atg14) encodes a protein involved in autophagy. | Death executioner Bcl-2 (Debcl) encodes a pro-apoptotic member of the Bcl-2 family involved in programmed cell death. | 0.698 |
Atg14 | Pi3K59F | FBpp0084739 | FBpp0071973 | Autophagy-related 14 (Atg14) encodes a protein involved in autophagy. | Phosphatidylinositol 3-kinase catalytic subunit type 3; Phosphotidylinositol 3 kinase 59F (Pi3K59F) encodes a lipid kinase that is required for formation of Phosphatidylinositol 3-phosphate. It functions in a core protein complex that includes the products of Atg6 and Vps15. It is involved in the control of vesicle trafficking, including autophagy, endocytosis and phagocytosis. | 0.999 |
Atg14 | Rubicon | FBpp0084739 | FBpp0304117 | Autophagy-related 14 (Atg14) encodes a protein involved in autophagy. | Uncharacterized protein, isoform A; Phosphatidylinositol phosphate binding. It is involved in the biological process described with: negative regulation of autophagy. | 0.797 |
Atg14 | Uvrag | FBpp0084739 | FBpp0080039 | Autophagy-related 14 (Atg14) encodes a protein involved in autophagy. | UV-resistance associated gene (Uvrag) encodes a protein that regulates autophagy and vesicle trafficking with the product of Atg6 and class C vacuolar protein sorting complexes. With the products of Atg6 and Pi3K59F, It forms a PI3K(III) complex and plays roles in receptor downregulation and the establishment of proper cell polarity. It is also critical for proper organ rotation during development by controlling receptor endocytosis and subsequent degradation. | 0.997 |
Atg14 | Vps15 | FBpp0084739 | FBpp0081466 | Autophagy-related 14 (Atg14) encodes a protein involved in autophagy. | Vacuolar protein sorting 15 (Vps15) encodes a serine/threonine protein kinase that is a core component of the Vps34/class III PI3-Kinase complex. It is required for the production of PI3P and influences multiple vesicle trafficking pathways, including autophagy and endocytosis. | 0.999 |