STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG6523LD40224p; Protein disulfide oxidoreductase activity; electron transfer activity. It is involved in the biological process described with: cellular iron ion homeostasis; cell redox homeostasis. (216 aa)    
Predicted Functional Partners:
CG33672
GEO02273p1; Iron-sulfur cluster binding. It is involved in the biological process described with: cellular iron ion homeostasis; [2Fe-2S] cluster assembly.
  
 
 0.995
CIAPIN1
Anamorsin homolog; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the cytosolic Fe-S scaffold complex. Electrons are transferred from NADPH via a FAD- and FMN-containing diflavin oxidoreductase. Together with the diflavin oxidoreductase, also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RN [...]
    
 
 0.991
CG31126
Uncharacterized protein; It is involved in the biological process described with: transcription, DNA-templated; Belongs to the BolA/IbaG family.
  
 
 0.978
Grx1
Glutaredoxin 1 (Grx1) encodes a protein involved in copper ion homeostasis.
  
 
 0.850
MagR
Iron-sulfur cluster assembly 1 homolog, mitochondrial; Involved in the assembly of mitochondrial iron-sulfur proteins. Probably involved in the binding of an intermediate of Fe/S cluster assembly (By similarity). Required for maintenance of circadian rhythms under constant darkness.
  
 
 0.848
Grx1t
Glutaredoxin 1, testis-specific; Electron transfer activity; protein disulfide oxidoreductase activity; glutathione-disulfide reductase activity. It is involved in the biological process described with: cellular response to oxidative stress; cell redox homeostasis.
  
 
 0.846
CG8043
GH14121p; RNA binding. It is involved in the biological process described with: iron-sulfur cluster assembly.
   
  
 0.821
grn
Grain, isoform C; Grain (grn) encodes a transcription factor from the GATA family. It regulates the expression of receptors and adhesion molecules such as those encoded by unc-5 and Fas2 involved in axon guidance. It contributes to multiple other developmental processes including leg and larval spiracle morphogenesis.
    
 
 0.791
ABCB7
ATP binding cassette subfamily B member 7 (ABCB7) encodes a transporter that likely dimerizes to form a functional transporter. It may act in the mitochondria to transport substrates necessary for the maturation of ICS proteins, which are involved in iron homeostasis.
   
  
 0.780
IscU
Iron-sulfur cluster assembly enzyme; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.
  
 
 0.772
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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