Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ProtBProtamine B (ProtB) encodes a protamine protein involved in packaging the paternal genome in sperm. Protamines are small highly basic proteins with numerous cysteines. (144 aa)    
Predicted Functional Partners:
Mst77F
Histone-like protein 18C; Not known. Encoded in the intron of cAMP-dependent protein kinase regulatory chain type I.
   
  
 0.943
Tpl94D
Transition protein-like 94D (Tpl94D) encodes a HMG-box domain protein that is expressed during chromatin reorganization in spermatids.
   
  
 0.911
P32
CG6459 protein; P32 (P32) encodes an evolutionarily conserved mitochondrial protein that functions in presynaptic calcium signaling and neurotransmitter release as well as chromatin metabolism.
   
 
 0.893
Prtl99C
Protamine-like 99C (Prtl99C) encodes a sperm chromatin-associated protein that is essential for male fertility. It acts additively together with the products of Mst77F, ProtA and ProtB to compact the paternal chromatin; Belongs to the UPF0771 family.
   
  
 0.890
CG32371
MIP05284p; Microtubule binding; microtubule plus-end binding. It is involved in the biological process described with: protein localization to microtubule; protein localization to microtubule plus-end; regulation of microtubule polymerization or depolymerization; spindle assembly.
   
  
 0.823
tHMG1
Testis-enriched HMG-box-containing protein 1 (tHMG1) encodes a chromosomal protein involved in spermatogenesis.
   
 
 0.812
tHMG2
Testis-enriched HMG-box-containing protein 2 (tHMG2) encodes a chromosomal protein involved in spermatogenesis.
   
 
 0.786
CG31226
GEO08871p1.
   
    0.766
CG31468
GEO08873p1.
   
  
 0.766
His2Av
Histone H2A.v; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. Acts as a Polycomb group (PcG) protein required to maintain the transcriptionally repre [...]
   
 
 0.762
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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