STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
Semp1Seminal metalloprotease-1 (Semp1) encodes a metalloprotease that is produced by male accessory glands and transferred to females during mating. It is cleavage activated during mating, first by the product of Sems and then by auto-catalysis. The product of also cleaves at least two other seminal proteins, encoded by Acp26Aa and Acp36DE, in the mated female. (251 aa)    
Predicted Functional Partners:
CG9997
Uncharacterized protein, isoform A; CG9997 encodes a protein with homology to serine-type endopeptidases, but is not predicted to have catalytic activity due to mutations in its active site. It is produced in the male accessory gland and transferred to females during mating. In males, it is required for other seminal proteins to be transferred to mated females. In mated females, it is required for the binding of the product of SP to sperm and for the maintenance of long-term post-mating responses.
   
  
 0.922
Acp36DE
Accessory gland protein Acp36DE; Responsible for physiological and behavioral changes in mated female flies. Associates with sperm and localizes to specific regions of the female reproductive tract, including the sperm storage organs. It accelerates sperm accumulation into storage but does not mediate the entry of the first sperm into storage. Once sperm storage has initiated it seems to act as a guidance factor helping subsequent sperm move into storage, a corral concentrating sperm around the SSO entrances and/or a trigger for responses within the female that accelerate storage of sperm.
   
  
 0.919
Sems
Seminase (Sems) encodes a serine protease produced in male's accessory glands and transferred to females during mating. It is an essential component in the pathway for proteolytic processing of different seminal proteins. It cleaves the metalloprotease encoded by Semp1, which in turn also cleaves the seminal proteins encoded by Acp26Aa and Acp36DE. It is also required for sperm release from storage via regulation of the product of SP.
   
  
 0.912
Acp26Aa
Accessory gland protein 26Aa (Acp26Aa) encodes a protein synthesized in male accessory glands. It is transferred during mating to females where it induces an increase in ovulation by relaxing the oviduct via activation of octopaminergic signaling.
   
  
 0.871
Acp62F
Accessory gland protein Acp62F; Responsible for physiological and behavioral changes in mated female flies. May contribute to the toxicity of seminal fluid and the decreased life-span of mated females. May also affect neuromuscular events after mating concerning sperm storage and egg release.
   
  
 0.861
lectin-46Cb
lectin-46Cb (lectin-46Cb) encodes a protein with homology to C-type lectins. It is produced in the male accessory gland and transferred to females during mating. In mated females, is required for the binding of product of SP to sperm, and for maintenance of long-term post-mating responses.
   
 
 0.853
lectin-46Ca
lectin-46Ca (lectin-46Ca) encodes a protein with homology to C-type lectins. It is produced in the male accessory gland and transferred to females during mating. In mated females, it binds to sperm in the seminal receptacle. It is required for the binding of the product of SP to sperm, and for maintenance of long-term post-mating responses.
   
 
 0.850
CG17575
Uncharacterized protein, isoform B; CG17575 encodes a cysteine-rich secretory protein produced in the male accessory glands and transferred to females during mating. In mated females, it is required for the binding of the product of SP to sperm and for the consequent maintenance of long-term post-mating responses.
   
  
 0.843
CG11037
CG11037 protein; Serine-type endopeptidase activity. It is involved in the biological process described with: proteolysis; multicellular organism reproduction; Belongs to the peptidase S1 family.
   
  
 0.831
CG6168
Uncharacterized protein, isoform B; CG6168 encodes a predicted metalloendopeptidase that is produced by the male accessory glands. CG6168 ectopic expression in females provides anti-microbial protection.
   
  
 0.829
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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