Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Nepl8Neprilysin-like 8; Metalloendopeptidase activity. It is involved in the biological process described with: proteolysis. (619 aa)    
Predicted Functional Partners:
Nepl11
Neprilysin-like 11; Metalloendopeptidase activity. It is involved in the biological process described with: proteolysis.
      
 0.892
Nepl9
Neprilysin-like 9; Metalloendopeptidase activity. It is involved in the biological process described with: proteolysis.
      
 0.652
Nepl19
Neprilysin-like 19; Metalloendopeptidase activity. It is involved in the biological process described with: proteolysis.
      
 0.652
Nepl17
Neprilysin-like 17; Metalloendopeptidase activity. It is involved in the biological process described with: proteolysis.
      
 0.649
Nepl14
Neprilysin-like 14; Metalloendopeptidase activity. It is involved in the biological process described with: proteolysis.
   
  
 0.605
goe
Protein gone early; Plays a role in the ovary in limiting the number of primordial germ cells (PGCs) that develop directly into gametes, allowing them instead to enter the developmental pathway that produces germline stem cells (GSCs) from PGCs and ensuring lifelong production of gametes from these GSCs. Negatively regulates epidermal growth factor receptor (Egfr) signaling. Probably down-regulates EGFR signaling on intermingled cells, a type of somatic stromal cell which contacts PGCs, and the resultant low level of signaling limits the proportion of PGCs which start gametogenesis, ma [...]
      
 0.594
Ide
Insulin-degrading enzyme; Insulin degrading metalloproteinase (Ide) encodes a metalloprotease that controls growth in a cell-autonomous manner by regulating the level of the insulin-like peptide encoded by Ilp2.
      
 0.462
Acp76A
Accessory gland protein 76A (Acp76A) encodes a protein that shows homology to the serpin serine endopeptidase inhibitor family but is predicted to be non-inhibitory. It is produced in the male accessory glands and transferred to females during mating.
     
  0.400
Spn28B
Serpin 28B, isoform A; Serine-type endopeptidase inhibitor activity. It is involved in the biological process described with: negative regulation of proteolysis; negative regulation of endopeptidase activity; multicellular organism reproduction; Belongs to the serpin family.
     
  0.400
Spn28F
Serpin 28F (Spn28F) encodes a predicted serine protease inhibitor. It is expressed in the male accessory glands and transferred to females during mating.
     
  0.400
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.