Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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dacDachshund, isoform B; Dachshund (dac) encodes a transcriptional cofactor that physically interacts with several other retinal determination proteins, including those encoded by eya and so, and regulates eye, leg, gonad, and brain development. (1081 aa)    
Predicted Functional Partners:
eya
Developmental protein eyes absent; Tyrosine phosphatase thought to play a role in transcription regulation during organogenesis through its intrinsic protein phosphatase activity. The phosphatase activity was shown in vitro. Appears to function together with So and Dac in eye development. Required for the survival of eye progenitor cells at a critical stage in morphogenesis. Belongs to the HAD-like hydrolase superfamily. EYA family.
   
 
 0.999
ey
Paired box protein Pax-6; Eyeless (ey) encodes a transcription factor that is involved in eye development as part of the retinal determination gene network, and contributes to brain formation.
   
 
 0.978
so
Sine oculis (so) encodes a homeobox-containing transcription factor that functions with the product of eya as a transcriptional co-activator. It contributes to both cell and tissue fate specification, promotion of cell proliferation and suppression of apoptosis.
   
 
 0.919
dan
Protein distal antenna; Probable transcription factor with a role in the retinal determination (RD) network. Regulates ato expression and is required for normal R8 induction and differentiation. Danr appears to repress Dan expression, but Dan is required for Danr expression anterior to the morphogenetic furrow (MF). Dan and Danr lie downstream of so and require dac function for highest levels of expression. Contributes to differentiation of antenna-specific characteristics; effector gene that acts downstream of homothorax (hth), Distal-less (Dll), cut (ct) and spineless (ss) genes to c [...]
    
 
 0.906
Optix
Optix (Optix) encodes a homeobox containing DNA binding protein and a member of the SIX class of proteins. It functions as a repressor via interaction with the transcriptional co-repressor encoded by gro. It is involved in eye formation and morphogenetic furrow movement.
   
 
 0.853
P58IPK
LD25575p; Misfolded protein binding; chaperone binding. It is involved in the biological process described with: protein folding in endoplasmic reticulum.
    
   0.819
Six4
Homeobox protein SIX4; Six4 (Six4) encodes a homeodomain-containing transcription factor required for mesodermal patterning to form the embryonic gonad.
    
 
 0.795
Hydr1
Alpha/beta hydrolase 1, isoform A; Short-chain carboxylesterase activity; acylglycerol lipase activity; acetylesterase activity; lipase activity. It is involved in the biological process described with: lipid metabolic process; cellular lipid metabolic process.
      
 0.749
Dll
Homeotic protein distal-less; Transcription factor that plays a role in larval and adult appendage development. Specifies the identity of ventral appendages (including legs and antennae) and suppresses dorsal appendage development. Involved in patterning the distal-proximal limb axis. May control the adhesive properties of cells during limb morphogenesis. Also has a secondary role in the normal patterning of the wing margin.
   
  
 0.674
Set
Set (Set) encodes a subunit of the inhibitor of histone acetyltransferase (INHAT) complex, which controls histone acetylation. It is involved in transcriptional regulation, which ultimately controls different processes such as p53-mediated apoptosis and neuronal development.
    
   0.666
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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