STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG6012MIP25013p; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (308 aa)    
Predicted Functional Partners:
Had2
Beta hydroxy acid dehydrogenase 2; 3-hydroxyacyl-CoA dehydrogenase activity. It is involved in the biological process described with: fatty acid metabolic process; oxidation-reduction process.
   
  
 0.864
P5cr
Pyrroline-5-carboxylate reductase activity. It is involved in the biological process described with: oxidation-reduction process; L-proline biosynthetic process.
     
 0.845
Sc2
Sc2; Oxidoreductase activity; oxidoreductase activity, acting on the CH-CH group of donors. It is involved in the biological process described with: very long-chain fatty acid biosynthetic process.
   
 
 0.751
Cyp6t1
Probable cytochrome P450 6t1; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
  
 
 0.691
Hayan
Serine protease Hayan; Serine protease which, by converting prophenoloxidase 1 (PPO1) into its active form, plays an essential role in the melanization immune response to physical or septic wounding. May function in diverse PPO1-activating cascades that are negatively controlled by different serpin proteins; Spn27A and Spn28D in the hemolymph, and Spn28D and Spn77BA in the trachea. Also required in the systematic wound response by mediating the redox-dependent activation of the JNK cytoprotective cascade in neuronal tissues after integument wounding; Belongs to the peptidase S1 family. [...]
      
 0.600
Cyp6a13
Probable cytochrome P450 6a13; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
  
 
 0.586
Hacd1
Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...]
   
 
 0.526
Pdh
Photoreceptor dehydrogenase (Pdh) encodes a retinal pigment cell dehydrogenase involved in retinol metabolism; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
 
 
 
 0.516
Hacd2
Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...]
   
 
 0.495
CG33288
HDC11342; Chromatin binding; Ran guanyl-nucleotide exchange factor activity. It is involved in the biological process described with: Ran protein signal transduction; regulation of mitotic spindle assembly.
   
 
 0.495
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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