STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG17996COX assembly mitochondrial protein; Copper ion binding. It is involved in the biological process described with: mitochondrial cytochrome c oxidase assembly. (118 aa)    
Predicted Functional Partners:
CG9065
LP17418p; Copper chaperone activity. It is involved in the biological process described with: copper ion transport; respiratory chain complex IV assembly; mitochondrial cytochrome c oxidase assembly.
   
  
 0.632
CG13018
GEO10184p1; It is involved in the biological process described with: mitochondrial cytochrome c oxidase assembly.
   
  
 0.615
CG5131
Mitochondrial inner membrane protease ATP23; Metalloendopeptidase activity. It is involved in the biological process described with: mitochondrial proton-transporting ATP synthase complex assembly; mitochondrial protein processing.
   
  
 0.576
CG15525
MIP04834p.
   
  
 0.568
Tim10
Mitochondrial import inner membrane translocase subunit Tim10; Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity); Belongs to the small Tim family.
   
  
 0.549
CG42497
GEO02620p1; It is involved in the biological process described with: regulation of dopamine metabolic process.
   
  
 0.527
ND-B18
NADH dehydrogenase activity; NADH dehydrogenase (ubiquinone) activity. It is involved in the biological process described with: mitochondrial electron transport, NADH to ubiquinone.
   
  
 0.498
Pfdn6
Probable prefoldin subunit 6; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity); Belongs to the prefoldin subunit beta family.
   
  
 0.473
mRpL32
39S ribosomal protein L32, mitochondrial; Structural constituent of ribosome. It is involved in the biological process described with: translation; mitochondrial translation.
   
    0.435
pum
Maternal protein pumilio; Sequence-specific RNA-binding protein that acts as a post- transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'- UGUANAUA-3', that is related to the Nanos Response Element (NRE). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of deadenylase complexes leading to translational inhibition and mRNA degradation (By similarity). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs. Me [...]
    
   0.435
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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