Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
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experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
cassApoptosis inhibitor 5 homolog; Antiapoptotic factor. Also known to efficiently suppress E2F1-induced apoptosis. (536 aa)    
Predicted Functional Partners:
RpII140
DNA-directed RNA polymerase II subunit RPB2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is [...]
   
  
 0.947
Acn
Acinus, isoform A; Acinus (Acn) encodes nuclear protein that, together with the products of a Bin1 and RnpS1, forms the ASAP complex that contributes to the regulation of alternative splicing. The Acn protein also functions in basal, starvation-independent autophagy.
   
 
 0.906
TBC1D23
Uncharacterized protein; GTPase activator activity. It is involved in the biological process described with: positive regulation of intracellular transport; retrograde transport, endosome to Golgi; regulation of GTPase activity.
   
   0.892
Hel25E
ATP-dependent RNA helicase WM6; Required for mRNA export out of the nucleus. Probable RNA helicase that may regulate entry into mitosis by down-regulating the expression of other genes whose activity may be rate-limiting for entry into mitosis during embryogenesis. Binds to salivary gland chromosomes and modifies position effect variegation. Promotes an open chromatin structure that favors transcription during development by regulating the spread of heterochromatin.
   
 
 0.836
CG11436
LD19190p; It is involved in the biological process described with: actin filament polymerization.
      
 0.734
Rpn7
26S proteasome non-ATPase regulatory subunit 6; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
      
 0.733
Gpb5
Glycoprotein hormone beta 5 (Gpb5) encodes a ligand of the G protein-coupled receptor encoded by Lgr1. It is involved in hormone-mediated signaling.
      
 0.728
RpIII128
DNA-directed RNA polymerase III subunit RPC2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the clef [...]
   
  
 0.712
CG5110
Ragulator complex protein LAMTOR3 homolog; CG5110 encodes a scaffold protein that associates with the MAP kinase kinase and the MAP kinase encoded by Mekk1 and rl respectively. It regulates the vein promoting function of rl during wing imaginal disc development in third instar larvae; Belongs to the LAMTOR3 family.
      
 0.666
tau
Microtubule-associated protein; Microtubule binding. It is involved in the biological process described with: neuron projection development; rhabdomere morphogenesis; negative regulation of neuron death; microtubule cytoskeleton organization.
    
   0.655
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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