STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
Grip71Grip71; Gamma-tubulin binding. It is involved in the biological process described with: centrosome cycle; protein localization to centrosome; regulation of cell cycle; spindle assembly involved in female meiosis I; mitotic cell cycle. (646 aa)    
Predicted Functional Partners:
Grip75
Gamma-tubulin complex component 4 homolog; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family.
   
 0.996
Grip128
Grip128 (Grip128) encodes a component of the Gamma-tubulin ring complex, which is a potent microtubule nucleator in eukaryotic cells essential for successful chromosome segregation and cell division.
   
 0.992
Mzt1
Mitotic spindle organizing protein 1; Gamma-tubulin binding. It is involved in the biological process described with: gamma-tubulin complex localization; microtubule nucleation by interphase microtubule organizing center; mitotic spindle assembly.
    
 0.984
Grip91
Gamma-tubulin complex component 3; Gamma-tubulin ring protein 91 (Grip91) encodes a gamma-tubulin binding protein involved in male meiotic division and the organization of the meiotic spindle; Belongs to the TUBGCP family.
   
 0.976
Grip84
Gamma-tubulin complex component 2 homolog; Gamma-tubulin binding; microtubule minus-end binding.
   
 0.976
Grip163
Grip163 (Grip163) encodes a gamma-tubulin binding protein involved in the mitotic cell cycle.
   
 0.976
gammaTub23C
Tubulin gamma-1 chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly.
   
 0.974
gammaTub37C
Tubulin gamma-2 chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly. Required for oocyte activation and consequently for organization of the female meiotic spindle. Essential for centrosome organization and assembly of biastral mitotic spindles in embryos. Plays a role in stabilizing the augmin complex on the meiotic spindle.
   
 0.952
CG18109
GCP_N_terminal domain-containing protein; Gamma-tubulin binding; microtubule minus-end binding. It is involved in the biological process described with: spindle assembly; mitotic cell cycle; microtubule nucleation by interphase microtubule organizing center; cytoplasmic microtubule organization; meiotic cell cycle.
    
 0.890
cnn
Centrosomin (cnn) encodes an essential mitotic centrosome component. During early embryogenesis it is required to organize the mitotic spindle, the actin cytoskeleton and centriole replication. It is also required for mitotic and meiotic divisions during spermatogenesis, as well as organization of the sperm axoneme. The product of cnn can interact with microtubules, actin and the kinase encoded by polo.
    
 
 0.878
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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