STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG10376SD03870p; Magnesium-dependent protein serine/threonine phosphatase activity; protein serine/threonine phosphatase activity. It is involved in the biological process described with: protein dephosphorylation; negative regulation of protein kinase activity. (428 aa)    
Predicted Functional Partners:
CG1750
Uncharacterized protein; methionyl-tRNA formyltransferase activity. It is involved in the biological process described with: conversion of methionyl-tRNA to N-formyl-methionyl-tRNA; biosynthetic process.
  
   0.651
Cul2
Cullin 2 (Cul2) encodes a protein that plays important roles during oogenesis. Reduction of the product of Cul2 in somatic cells produces tumorous germaria with excess germline stem cell-like cells due to the elevation of Dpp signaling in the niche; Belongs to the cullin family.
   
  
 0.630
Erk7
Extracellular signal-regulated kinase 7; Atypical MAPK protein that regulates protein secretion in a kinase activity-dependent manner. In response to starvation regulates protein secretion by mediating transitional endoplasmic reticulum site disassembly. Mediates inhibition of insulin-like peptide secretion upon disturbed ribosome biogenesis and acts as a downstream effector of TP53.
   
 
 0.622
Lrrk
Leucine-rich repeat kinase (Lrrk) encodes a large Ser/Thr kinase involved in mRNA translational control, cytoskeleton regulation, vesicle trafficking, autophagy, and immune response.
  
 
 0.594
CG42327
IP14232p; Protein tyrosine phosphatase activity. It is involved in the biological process described with: protein dephosphorylation.
    
 
 0.557
CG31469
GEO10716p1; Protein arginine phosphatase activity; protein tyrosine phosphatase activity. It is involved in the biological process described with: peptidyl-N-phospho-arginine dephosphorylation.
      
 0.551
PpV
Protein phosphatase V (PpV) encodes the catalytic subunit of the protein phosphatase 6 (PP6), which negatively regulates JNK and AMPK signaling. PpV product is essential for lipid homeostasis and Ras-induced tumorigenesis; Belongs to the PPP phosphatase family. PP-6 (PP-V) subfamily.
   
 
 0.545
CG32812
EG:114D9.1 protein; Calcium ion binding. It is involved in the biological process described with: negative regulation of phosphatase activity.
    
 
 0.541
Ptp36E
Protein tyrosine phosphatase 36E (Ptp36E) encodes a tyrosine-specific protein phosphatase. It is probably a cytoplasmic protein, as it lacks a predicted transmembrane domain, but little is known about its function.
    
 
 0.538
PTP-ER
Protein tyrosine phosphatase-ERK/Enhancer of Ras1 (PTP-ER) encodes a phosphatase required for mitosis. It is involved in RAS/MAPK signaling regulation and eye development.
   
 
 0.536
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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