Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Ttc19Tetratricopeptide repeat protein 19 homolog, mitochondrial; Required for mitochondrial complex III formation. (369 aa)    
Predicted Functional Partners:
UQCR-C2
Endopeptidase activity; metal ion binding; ubiquinol-cytochrome-c reductase activity. It is involved in the biological process described with: mitochondrial electron transport, ubiquinol to cytochrome c; protein processing involved in protein targeting to mitochondrion.
  
 
 0.785
RFeSP
Cytochrome b-c1 complex subunit Rieske, mitochondrial; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
    
 0.780
CG13585
MIP15530p.
      
 0.757
CG4908
RH68195p; ATP binding. It is involved in the biological process described with: mitochondrial respiratory chain complex III assembly; protein insertion into mitochondrial inner membrane from matrix; Belongs to the AAA ATPase family.
   
  
 0.757
SppL
Signal peptide peptidase-like, isoform D; Aspartic endopeptidase activity, intramembrane cleaving. It is involved in the biological process described with: membrane protein proteolysis; signal peptide processing.
   
  
 0.748
mt:Cyt-b
Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
     
 0.728
Cchl
Cytochrome c heme lyase; Links covalently the heme group to the apoprotein of cytochrome c.
   
  
 0.717
UQCR-C1
Metalloendopeptidase activity; ubiquinol-cytochrome-c reductase activity; metal ion binding; endopeptidase activity. It is involved in the biological process described with: protein processing; protein processing involved in protein targeting to mitochondrion; mitochondrial electron transport, ubiquinol to cytochrome c.
  
 
 0.685
ND-PDSW
NADH dehydrogenase (Ubiquinone) PDSW subunit, isoform A; NADH dehydrogenase activity. It is involved in the biological process described with: mitochondrial electron transport, NADH to ubiquinone.
      
 0.681
CG5270
Zinc finger FYVE domain-containing protein 26 homolog; Metal ion binding; phosphatidylinositol-3-phosphate binding. It is involved in the biological process described with: mitotic cytokinesis; double-strand break repair via homologous recombination; regulation of cytokinesis; Belongs to the ZFYVE26 family.
    
 
 0.658
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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