STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG10268Phosphomevalonate kinase activity. It is involved in the biological process described with: isopentenyl diphosphate biosynthetic process, mevalonate pathway; cholesterol biosynthetic process; isoprenoid biosynthetic process. (189 aa)    
Predicted Functional Partners:
CG33671
Mevalonate kinase activity; ATP binding. It is involved in the biological process described with: isopentenyl diphosphate biosynthetic process, mevalonate pathway; isoprenoid biosynthetic process; cholesterol biosynthetic process.
   
 
 0.994
Mvd
Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes.
   
 
 0.991
Idi
Hydrolase activity; isopentenyl-diphosphate delta-isomerase activity. It is involved in the biological process described with: isoprenoid biosynthetic process; isopentenyl diphosphate biosynthetic process.
   
  
 0.916
Hmgs
3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.
   
  
 0.901
Fpps
Farnesyl pyrophosphate synthase (Fpps) encodes a protein involved in germ cell migration; Belongs to the FPP/GGPP synthase family.
   
 
 0.827
Hmgcr
3-hydroxy-3-methylglutaryl-coenzyme A reductase; Synthesis of mevalonate for the production of non-sterol isoprenoids, which are essential for growth differentiation. Provides spatial information during embryogenesis to guide migrating primordial germ cells (the pole cells) from the ectoderm to the mesoderm. Also required for association of the pole cells with the gonadal mesoderm. Belongs to the HMG-CoA reductase family.
   
 
 0.822
Sras
CAAX prenyl protease 2; Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins; Belongs to the peptidase U48 family.
   
  
 0.618
CG9149
Uncharacterized protein; acetyl-CoA C-acetyltransferase activity; acetyl-CoA C-acyltransferase activity. It is involved in the biological process described with: fatty acid beta-oxidation; Belongs to the thiolase-like superfamily. Thiolase family.
   
 
 0.571
jhamt
Juvenile hormone acid O-methyltransferase; O-methyltransferase that transfers a methyl group from S- adenosyl-L-methionine (SAM) to the carboxyl group of juvenile hormone acids to produce active juvenile hormones in the corpora allata, the last step during juvenile hormone biosynthesis. Also able to methylate farnesoate to methyl farnesoate.
      
 0.553
CG10932
LD24105p; acetyl-CoA C-acetyltransferase activity; acetyl-CoA C-acyltransferase activity. It is involved in the biological process described with: fatty acid beta-oxidation; fatty acid biosynthetic process; pyruvate metabolic process; Belongs to the thiolase-like superfamily. Thiolase family.
   
 
 0.542
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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